AGE ASSOCIATED CHANGES IN VASCULAR STIFFNESS PROPERTIES

本报告的最终目标 该项目旨在确定动脉僵硬度特性如何影响 心肌结构和功能，并有助于心血管 发病率和死亡率。a.我们研究了 695名男性和616名男性的动脉硬度与左心室（LV）质量的关系 来自台湾的妇女（合同编号N01-AG-02 - 2118）。无论男女， 左室质量的主要预测因素是收缩压、体质量、 表面积和年龄; AGI贡献最小（r2小于或 等于0.006）与左心室质量的关系。B。以确定是否 生长激素或性类固醇补充剂改善动脉 缺乏这些的老年人的刚度特性 物质，我们正在测量男性的脉搏波速度和AGI 和65岁及以上的女性，在激素治疗前后 更换. C.我们正在测试的假设，1 - 2年的 家庭有氧运动训练可以降低动脉硬化， NIH赞助的810名多中心活动咨询试验 受试者年龄35 - 75岁。D.为了确定有氧运动 训练可以降低老年心脏动脉僵硬度 失败的患者，以及这种动脉僵硬度的变化是否 与训练引起的有氧运动能力的提高有关， 我们将测量动脉硬度和峰值VO2之前和之后的3 一个月的有氧训练计划。e.多中心研究， 确定动脉僵硬度是否是一个独立的风险因素， 老年自由生活者的心血管事件 与流行病学和人口统计学合作发起 NIA内部的生物统计学项目。F.后续行动 耐力训练老年男性动脉硬度的测量 最初在1989 - 1991年进行的研究表明， 以确定慢性耐力训练是否 减弱了正常的年龄相关的动脉硬度增加。 G.将在Pittsburgh，PA研究中心测量动脉硬度， 心血管健康研究，一个全面的表征 社区居民心血管结构和功能的研究 年龄≥ 65岁的临床健康男性和女性 老了对该队列的长期随访将使我们能够检查 老年人动脉硬化的预后意义 人口H.动脉僵硬度和一些 新发现的与钠和血压有关的激素 调节（血浆哇巴因样因子和海蟾毒配基）， 在BLSA受试者中进行检查， 压力范围I.我们开发了一种新的动脉指数， 函数，衰减指数，定义自 多普勒颈内动脉流速从峰值下降 收缩期至终末舒张期。

SUMMARY OF WORK The ultimate goals of this project are to determine how arterial stiffness properties influence myocardial structure and function and contribute to cardiovascular morbidity and mortality. A. We have examined the contribution of arterial stiffness to left ventricular (LV) mass in 695 men and 616 women from Taiwan (Contract #N01-AG-02-2118). In both sexes, the major predictors of LV mass were systolic blood pressure, body surface area and age; AGI contributed minimally (r2 less than or equal to 0.006) to LV mass in either sex. B. To determine whether growth hormone or sex steroid supplementation ameliorates arterial stiffness properties in older adults with deficiencies of these substances, we are measuring pulse wave velocity and AGI in men and women aged 65 years and older, before and after hormonal replacement. C. We are testing the hypothesis that 1-2 years of home-based aerobic exercise training can reduce arterial stiffness in the multicenter NIH-sponsored Activities Counseling Trial of 810 subjects 35-75 years old. D. To determine whether aerobic exercise training can reduce the elevated arterial stiffness of older heart failure patients and whether such changes in arterial stiffness are related to training-induced improvement of aerobic performance, we will measure arterial stiffness and peak VO2 before and after a 3 month program of aerobic training. E. A multicenter study to determine whether arterial stiffness is an independent risk factor for cardiovascular events in elderly free-living persons has been initiated in collaboration with the Epidemiology Demography Biometry Program of the intramural NIA. F. Follow-up measurements of arterial stiffness on endurance trained older men and their sedentary age peers, initially studied in 1989-1991 have been obtained to determine whether chronic endurance training attenuates the normal age-associated increase in arterial stiffness. G. Arterial stiffness will be measured in the Pittsburgh, PA site for the Cardiovascular Health Study, a comprehensive characterization of cardiovascular structure and function in community dwelling clinically healthy men and women greater than or equal to 65 years old. Long-term follow-up of this cohort will allow us to examine the prognostic significance of arterial stiffness in an older population. H. The relationship between arterial stiffness and some newly discovered hormones involved in sodium and blood pressure regulation (plasma ouabain-like factor and marinobufagenin) is being examined in BLSA subjects across a large age and blood pressure range. I. We have developed a novel index of arterial function, the Decay Index, defined from the exponential rate of decline in the Doppler internal carotid artery flow rate from peak systole to end-diastole.