EPIDEMIOLOGY STUDY OF THE LATE REPRODUCTIVE YEARS

这是对非洲人荷尔蒙和症状的纵向研究。 处于生育后期的美国和高加索妇女。这个 具体目标是：1)描述 选定激素的变化：卵泡刺激素(FSH)， 黄体生成素、雌二醇、睾酮和 脱氢表雄酮硫酸盐(DHEAS)；评估心理和 通常与生殖老化有关的身体症状；3) 将激素变化与症状的严重程度相关联；4)比较 非裔美国人和高加索女性之间的结果。《博大》 假设是：a)出现的心理和身体症状 与生殖老化有关的是波动或比率 激素变化；b)DHEAS，一种衰老的肾上腺激素标记物，可能 对心理症状有直接影响；c)心理 症状与血管舒缩症状无关，且发生在血管舒缩症状之前； 以及d)与非洲人相比，在症状和激素方面有什么不同 美国和高加索女性在控制了 已发现的区分这些群体的变量，例如 受教育程度、收入、婚姻状况和体重。 以人口为基础的400名妇女样本(200名非裔美国人，200名 高加索人)将通过随机数字拨号识别。女人们 注册时年龄在35-47岁之间，月经周期正常。六 每隔7-9个月进行一次的评估期将评估 研究随时间变化的变量。 超过80%的美国女性经历过心理或身体上的 在生殖衰退期的症状，有不同程度的 严重程度和正常功能的中断。这项前瞻性研究 将填补两国间关系知识的一个重要空白 生殖年末的激素变化和症状，并提供 关于非裔美国女性这些因素的第一个信息。在……里面 此外，这些发现将对临床医生解决 妇女晚育年龄和生育意愿的生育问题 加深我们对生殖衰老在老年妇女中作用的认识 绝经后妇女发病率和死亡率增加。

This is a longitudinal study of hormones and symptoms of African American and Caucasian women in their late reproductive years. The specific aims are to: 1) characterize the fluctuations and rates of changes of selected hormones: follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, testosterone and dehydroepiandrosterone sulfate (DHEAS); evaluate psychological and physical symptoms commonly associated with reproductive aging; 3) correlate hormone changes with the severity of symptoms; 4) compare the results between African American and Caucasian women. The broad hypotheses are that: a) psychological and physical symptoms which occur with reproductive aging are associated with the fluctuations or rates of hormonal changes; b) DHEAS, an adrenal hormone marker of aging, may have a direct effect on psychological symptoms; c) psychological symptoms are not correlated with and occur prior to vasomotor symptoms; and d) any difference in symptoms and hormones compared between African American and Caucasian women is negligible after controlling for variables that have been found to differentiate these groups, such as education, income, marital status and body mass. A population-based sample of 400 women (200 African American, 200 Caucasian) will be identified through random digit dialing. The women will be ages 35-47 with regular menstrual cycles at enrollment. Six assessment periods, conducted at 7-9 month intervals will evaluate the study variables over time. More than 80% of U.S. women experience psychological or physical symptoms in the waning reproductive years, with varying degrees of severity and disruption of normal functioning. This prospective study will fill an important gap in the knowledge of relationships between hormone changes and symptoms in the late reproductive years and provide the first information on these factors in African American women. In addition, the findings will be important for clinicians addressing fertility problems of women in their late reproductive years and will increase our understanding of the role of reproductive aging in the increased morbidity and mortality of postmenopausal women.