EFFECT OF INSULIN RESISTANCE ON THE LIPOPROTEIN RESPONSE TO EGG FEEDING

确定胰岛素抵抗或肥胖是否与血浆相关 蛋类摄入对血脂的反应，201名受试者将分为 三个相等的组，瘦胰岛素敏感组，瘦胰岛素抵抗组，和 肥胖胰岛素抵抗，使用胰岛素敏感指数或7.0 由频繁采样的静脉葡萄糖耐量试验和BMI&GT决定； 或27.5公斤/平方米。科目将从机构人员中招聘 和公共广告，教授NCEP第一步(适度低脂)饮食 并以双盲交叉设计喂养经过巴氏杀菌的全蛋和/或 鸡蛋替代品在三个随机的月度方案中，水平为0，2 或每天4个鸡蛋，间隔一个月的冲洗期。的影响 鸡蛋喂养将通过低密度脂蛋白-胆固醇的变化进行评估，还将通过 高密度脂蛋白、载脂蛋白B和密度梯度的垂直变化 脂蛋白图谱的分析图谱。

To determine if insulin resistance or obesity is associated with plasma lipid response to egg consumption, 201 subjects will be divided into three equal groups, lean insulin sensitive, lean insulin resistant, and obese insulin resistant, using an insulin sensitivity index < or > 7.0 determined by a frequently sampled IV glucose tolerance test and BMI > or < 27.5 kg/m2. Subjects will be recruited from institutional personnel and public advertising, taught the NCEP Step I (moderately low fat) diet and fed in a double-blind cross-over design pasteurized whole egg and/or egg substitute in three randomized monthly protocols at levels of 0, 2 or 4 eggs daily, separated by one month washout periods. The effect of egg feeding will be assessed by changes in LDL-cholesterol, and also by changes in HDL-cholesterol, apoprotein B and density gradient vertical analytical profiles of the lipoprotein pattern.