课题基金 / 基金详情

FAMILIES WITH GENETIC SUSCEPTIBILITY TO BREAST CANCER

FAMILIES WITH GENETIC SUSCEPTIBILITY TO BREAST CANCER
有乳腺癌遗传易感性的家庭
批准号：
6274587
负责人：
SOFIA DIANA MERAJVER
金额：
$2.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274587
关键词：
brca gene breast neoplasms cancer risk cell line clinical research family genetics gene expression gene mutation genetic susceptibility human genetic material tag human subject lymphocyte neoplasm /cancer genetics

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中文摘要
翻译
BRCA 1是位于染色体17 q21上的一个假定的肿瘤抑制基因， 导致乳腺和/或卵巢发育的终生风险为85% 携带BRCA 1生殖系突变的女性患上癌症。 分离 BRCA 1可能会提供对乳腺癌生物学的深入了解， 并导致对乳腺癌遗传易感性的预测性测试， 癌 来自表观常染色体异常家族的永生化淋巴细胞 乳腺癌的主要传播是我们的基本试剂 努力识别BRCA 1。
英文摘要
BRCA 1 is a putative tumor suppressor gene located on chromosome 17q21, conferring an 85% lifetime risk of developing breast and/or ovarian cancer on women carrying BRCA1 germline mutations. The isolation of BRCA1 will likely provide insight into the biology of breast cancer as well as lead to predictive testing for genetic susceptibility to breast cancer. Immortalized lymphocytes from families with apparent autosomal dominant transmission of breast cancer are essential reagents in our efforts to identify BRCA1.
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