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GEMCITABINE IN COMBINATION WITH RADIATION THERAPY IN PANCREATIC CANCER

GEMCITABINE IN COMBINATION WITH RADIATION THERAPY IN PANCREATIC CANCER
吉西他滨联合放射治疗治疗胰腺癌
批准号：
6274710
负责人：
CORNELIUS J MCGINN
金额：
$2.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274710
关键词：
antineoplastics clinical research clinical trial phase I combination cancer therapy drug screening /evaluation human subject human therapy evaluation neoplasm /cancer chemotherapy neoplasm /cancer radiation therapy pancreas neoplasms

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中文摘要
翻译
吉西他滨最近已被证明具有临床活性， 细胞毒性剂在晚期胰腺癌患者中的应用， 是一种有效的人胰腺癌细胞的放射增敏剂， 体外 第一阶段试验的目的是确定 吉西他滨联合放疗的耐受剂量（MTD） 治疗局部晚期、不可切除的 胰腺癌
英文摘要
Gemcitabine has been shown recently to have clinical activity as a cytotoxic agent in patients with advanced pancreatic cancer and is known to be a potent radiation sensitizer of human pancreatic cancer cells in vitro. This phase-I trial is designed to determine the maximum tolerable dose (MTD) of gemcitabine when combined with radiation therapy in the treatment of patients with locally advanced, unresectable pancreatic cancer.
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