EFFECT OF CISAPRIDE ON THE CORRECTED QT INTERVAL IN YOUNG PATIENTS

西沙必利是一种新的促动力剂， 通过胃肠道蠕动，并广泛用于治疗 胃食管反流和其他胃肠道疾病 儿童的运动能力。 最近，西沙必利与 复杂心电图校正QT间期延长 室性心律失常（尖端扭转型室速）和危及生命的事件 在少数孤立的患者中（1-3）。 此外，一名15岁的女孩， 先天性长QT综合征，用普萘洛尔控制良好， 心室起搏，但患有严重缺氧性脑病 在长QT综合征诊断之前受伤， 在开始西沙必利治疗几个月后， 因为 西沙必利和延长 校正QT间期沿着危及生命的心律失常，我们 建议检查西沙必利对校正QT间期的影响 服用这种药物的年轻患者。 我们打算获得 心电图（ECG）在大约35名年轻受试者之前， 在西沙必利期间，以及如果可能且临床允许，在西沙必利之后 局 3次采样时所有12个导联的QT间期 将通过以下方式记录、测量、校正心率间期： Bazett公式，并使用配对t检验进行比较。 的 这项研究的意义在于可能检测到潜在的 西沙必利对心室复极的不良影响 可能导致危及生命心律失常的心电图。 的 检测到顺铂对校正QT的不良影响 间隔（即延长）可能会影响本品的临床使用 广泛使用的药物，并可能有助于进一步 心室复极机制的研究， 室性心律失常

Cisapride is a new prokinetic agent that facilitates or restores motility through the gastrointestinal tract and is widely used to treat gastroesophageal reflux and other disorders of gastrointestinal motility in children. Recently, cisapride has been associated with prolongation of corrected QT interval on the electrocardiogram, complex ventricular arrhythmias (torsade de pointes) and life-threatening events in a few isolated patients (1-3). In addition, a 15 year old girl with the congenital long QT syndrome, well controlled with propranolol and ventricular pacing, but who had sustained severe hypoxic encephalopathic injury prior to the diagnosis of the long QT syndrome, expired unexpectedly several months after beginning cisapride therapy. Because of this reported association between cisapride and lengthening of the corrected QT interval along with life-threatening arrhythmias, we propose to examine the effect of cisapride on the corrected QT interval in young patients taking this medication. We intend to obtain electrocardiograms (ECG) in approximately 35 young subjects before, during, and, if possible and clinically permissible, after cisapride administration. The QT interval in all 12 leads at the 3 sampling intervals will be recorded, measured, corrected for the heart rate by Bazett's formula, and compared using the paired t test. The significance of this study is the possibe detection of potentially adverse effects of cisapride on ventricular repolarization measured on the ECG that could be lead to life-threatening arrhythmias. The detection of such an adverse effect of cisparide on the corrected QT interval (i.e. prolongation) could impact both the clinical use of this widely employed medication and possibly contribute to further investigation into the mechanisms of ventricular repolarization and ventricular arhythmias.