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GROWTH HORMONE RECEPTORS AND ACTIONS

GROWTH HORMONE RECEPTORS AND ACTIONS
生长激素受体和作用
批准号：
6274726
负责人：
CHRISTIN CARTER-SU
金额：
$2.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6274726
关键词：
biological signal transduction enzyme activity hormone receptor hormone regulation /control mechanism human genetic material tag molecular cloning phosphorylation protein tyrosine kinase receptor binding site directed mutagenesis somatotropin

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中文摘要
翻译
生长激素(GH)促进其受体酪氨酸磷酸化 和其他细胞蛋白质。酪氨酸激酶活性也能协同净化 与生长激素受体有关。这些结果表明，生长激素激活 生长激素受体相关的酪氨酸激酶可能是 生长激素的信号转导机制。我们的研究现在集中在 生长激素受体相关酪氨酸激酶的克隆及体外应用 诱变以确定其在生长激素的细胞作用中的作用。
英文摘要
Growth hormone (GH) promotes the tyrosyl phosphorylation of its receptor and other cellular proteins. Tyrosine kinase activity also co-purifies with the GH receptor. These results suggest that activation by GH of a GH receptor-associated tyrosine kinase may be an important step in the signal transduction mechanism for GH. Our research is now focused upon cloning the GH receptor-associated tyrosine kinase and using in vitro mutagenesis to determine its role in celluar actions of GH.
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