RHDNASE USE IN CYSTIC FIBROSIS PATIENTS YOUNGER THAN 5 YEARS OF AGE

脓性感染痰液在患者气道内积聚 囊性纤维化（CF）阻塞气道并引起慢性， 有症状感染者（1例）。CF中的痰液富含白细胞来源的 细胞外DNA，大大有助于异常 痰液粘弹性（2，3）。重组人DNA酶I（rhDNA酶）， 一种人体天然酶的复制品 细胞外DNA，显着改变粘弹性的性质， 体外CF痰液（4）。 rhDNase与a的气雾剂施用 呼吸机驱动的手持式雾化器改善肺功能 CF患者在开始治疗的几天内（5，6）。 长期 rhDNA酶的施用还减少了对胃肠外给药的需要。 呼吸道感染的抗生素治疗（7）。 目的 这项研究的目的是评估rhDNase在以下方面的有用性： 5岁以下的儿童。

Accumulation of purulent, infected sputum in the airways of patients with cystic fibrosis(CF) obstructs airways and causes chronic, symptomatic infection(1). Sputum in CF is rich in leukocyte-derived extracellular DNA that greatly contributes to the abnormal viscoelasticity of sputum (2,3). Recombinant human DNase I (rhDNase), a copy of the native human enzyme responsible for hydolyzing extracellular DNA, dramatically alters the viscoelastic properties of CF sputum in vitro (4). Aerosol administration of rhDNase with a pneumatically driven hand-held nebulizer improves pulmonary function in CF pateients within days of initiating therapy (5,6). Longer-term administration of rhDNase also reduces the need for parenteral antibiotic treatment of respiratory tract infections(7). The purpose of this investigation is to evaluate the usefulness of rhDNase in children who are younger than 5 years of age.