TREATMENT OF HEMISPATIAL NEGLECT WITH DOPAMINERGIC AGONISTS

偏侧空间忽视综合症与受损有关 右脑损害患者的功能康复。连 尽管在动物文献中有证据支持 多巴胺在控制注意力和忽视方面，只有一种 很少有研究评价药物干预对人类忽视的影响 综合症。该项目的总体目标是了解患者是否 有偏侧空间忽视的患者将受益于多巴胺激动剂治疗。在……里面 特别是，我们建议用溴隐亭治疗中风患者。 牵涉到右侧纹状体。我们将检查哪些(如果有的话) 定向注意的行为成分(探索性--运动或感觉-- 代表性)改进。

The syndrome of hemispatial neglect has been associated with impaired functional rehabilitation of patients with right hemisphere damage. Even though there is evidence in the animal literature to support the role of dopamine in the control of attention and neglect, there have been only a few studies evaluating pharmacologic intervention in the human neglect syndrome. The overall aim of this project is to learn whether patients with hemispatial neglect would benefit from dopamine agonist therapy. In particular, we propose to treat (with bromocriptine) patients with strokes involving the right striatum. We will examine which if any of the behavioral components of directed attention (exploratory-motor or sensory- representational) improve.