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AMELIORATION OF HIV WASTING--EXERCISE AND MEGESTROL ACETATE

AMELIORATION OF HIV WASTING--EXERCISE AND MEGESTROL ACETATE
改善艾滋病毒消瘦——运动和醋酸甲地孕酮
批准号：
6275285
负责人：
JAMIE H VON ROENN
金额：
$2.26万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275285
关键词：
AIDS AIDS therapy body composition cachexia clinical research exercise human subject human therapy evaluation outcomes research pregnane compound weight loss

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中文摘要
翻译
不由自主的体重减轻或消瘦表明严重的蛋白质能量 营养不良是艾滋病的常见并发症。由于浪费了关联 艾滋病的特征是肌肉质量下降，而且因为 艾滋病患者的预后随着脱脂体重的丧失而恶化，我们 假设一个渐进式阻力和有氧运动项目 与甲地孕酮联合使用的处方将导致更大的 患者瘦体重的增加比单独进行干预要好 与艾滋病相关的减肥。
英文摘要
Involuntary weight loss or wasting indicative of severe protein energy malnutri-tion is a frequent complication of AIDS. Since wasting associated with AIDS is characterized by a loss of muscle mass, and because the prognosis for patients with AIDS worsens with the loss of fat free mass, we hypothesize that a program of progressive resistance and aerobic exercise prescribed in combination with megestrol acetate will result in greater increases in lean body mass than either intervention alone for patients with AIDS-related weight loss.
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