GENETIC STUDIES OF OBSESSIVE COMPULSIVE DISORDER--BLOOD COLLECTION PHASE

我们正在识别其中有多个一级成员的家庭 强迫症(OCD)的诊断。这些家庭是 来自任何来源的身份，包括约翰·霍普金斯大学的推荐 社区中的临床医生和私人治疗师。主题是 接受精神科医生和临床心理学家的检查。我们的目标是 对所有家庭成员进行临床评估并采集血样 从每个人身上取样本。用于未来提取DNA的细胞系正在进行 发展起来的。到目前为止，我们已经对15名31名受试者进行了临床检查。 以这种方式确认家庭身份，并从 他们。一旦采访了足够数量的受试者， 采集了血液样本，我们将做好准备进行基因研究 这些家庭，包括联系和联合战略。 最终目的是找出参与骨髓瘤发生发展的基因(S) 这是一种混乱。这将澄清强迫症的病理生理学，并导致 更合理的治疗方法。

We are identifying families in which multiple first-degree members have a diagnosis of obsessive-compulsive disorder (OCD). These families are being identified from any source, including referrals from Johns Hopkins clinicians and private therapists in the community. The subjects are being examined by psychiatrists and clinical psychologists. The aim is to clinically evaluate all the family members and to obtain a blood sample from each. Cell lines for future DNA extraction are being developed. To date, we have clinically examined 31 subjects in 15 families identified in this manner, and obtained blood samples from them. Once an adequate number of subjects has been interviewed and blood samples collected, we will be poised to proceed to genetic studies of these families, including both linkage and association strategies. The ultimate goal is to identify gene(s) involved in the development of the disorder. This will clarify the pathophysiology of OCD and lead to more rational treatments.