CALCIUM KINETICS WITH HISTORIES OF OSTEOPOROSIS

低骨量家族史是骨质疏松症发生的危险因素。 但导致这一发现的机制并不是 我知道。低骨量家族史改变的可能性 钙代谢在年轻女孩中可能最为明显，因为 大多数骨量是在16岁之前获得的 女性。这项研究的目标是确定年轻女孩是否来自 有骨质疏松症史的家庭在他们的 吸收钙并将其储存到骨骼中的能力。三个星期 在每次临床研究之前，每个女孩都吃高钙饮食。 选择用来提供目前 推荐给青春期女孩。在每个学习的当天有两个特别的 每个女孩都得到了各种形式的钙示踪剂，这样我们就可以跟踪 在接下来的5天内钙进入骨骼的清除。至 到目前为止，我们已经完成了对3名女孩的临床研究 有强烈的骨质疏松症病史，将再招募7名女孩参加 这项研究。尽管现在评论我们的结果还为时过早，但这 信息将提供有关以下建议的有用信息 来自骨质疏松症家庭的孩子。

A family history of low bone mass is a risk factor for the development of osteoporosis but the mechanisms responsible for this finding are not know. The potential for a family history of low bone mass to alter calcium metabolism may be most apparent in young girls because the majority of bone mass is obtained prior to the age of 16 years in females. The goals of this study are to determine if young girls from families with histories of osteoporosis have alternations in their ability to absob calcium and deposit it into bone. For three weeks before each clinical study, each girl consumes a high calcium diet chosen to provide the amount of calcium which is currently being recommended for adolescent girls. On the day of each study two special forms of calcium tracers are given to each girl so that we can follow the clearance of calcium into bone over the following 5 days. To date,we have completed the clinical study in 3 girls from families with strong histories of osteoporosis, and 7 more girls will be recruited for this study. Although it is too early to comment on our results, this information will provide useful information on the recommendations for children from osteroporotic families.