OVARIAN CANCER GENE THERAPY WITH BRCA1

我们正在研究阻止卵巢癌生长的可能性。 通过增加与遗传有关的主要基因的表达 卵巢癌，BRCA1。我们已经证明了BRCA1的基因转移 转化为癌细胞，抑制其生长，减少肿瘤的发生 裸鼠体内的人类癌细胞。因为BRCA1似乎是一种秘密的 生长抑制因子，是基因治疗研究的理想基因，因为 显然只转导了中等比例的肿瘤细胞 产生足够的生长抑制物来抑制所有的肿瘤细胞。这个 这项研究的目的是使用一种禁用的老鼠病毒来引入 将BRCA1基因导入卵巢癌细胞，确定这是否会抑制 癌细胞在患者体内的生长和扩散。我们是 几乎完成了这项研究的招聘阶段，因此每年 随访检查外周血中是否有逆转录病毒载体 其他测试目前还需要我们的关注。

We are studying the possibility of arresting the growth of ovarian cancer by increasing expression of the major gene responsible for hereditary ovarian cancer, BRCA1. We have demonstrated that gene transfer of BRCA1 into cancer cells inhibits their growth and reduces tumorigenesis of human cancer cells in nude mice. Because BRCA1 appears be a secreted growth inhibitor, it is an ideal gene for gene therapy studies because transduction of only a moderate percentage of tumor cells apparently produces enough growth inhibitor to inhibit all tumor cells. The purpose of this study is to use a disabled mouse virus to introduce the BRCA1 gene into ovarian cancer cells to determine if this will inhibit the growth and spread of the cancer cells within the patient. We are almost finished with the recruitment phase of this study, thus the yearly follow up examines for retroviral vector in the peripheral blood and other tests will require our attentions currently.