NORTH AMERICAN STUDY OF TREATMENT FOR REFRACTORY ASCITES (NASTRA)

这项由NIH申办的多中心随机临床试验旨在 比较经颈静脉肝内门体静脉插管的安全性和有效性 腹腔分流术（TIPS）治疗难治性腹水 患者 TIPS对门静脉病理生理的影响 并会检查高血压。 待检查的其他终点 包括护理费用、生活质量、利尿剂剂量、对肝脏需求 移植和营养状况。

This NIH-sponsored, multicenter randomized clinical trial is designed to compare the safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) to total paracentesis for refractory ascites in cirrhotic patients. The effects of TIPS on the pathophysiology of portal hypertension will also be examined. Additional endpoints to be examined include cost of care, quality of life, diuretic doses, need for liver transplantation and nutritional status.