课题基金 / 基金详情

PIVOTAL EFFICACY STUDY OF INHIBITION OF GASTRIC ACID SECRETION BY PANTOPRAZOLE

PIVOTAL EFFICACY STUDY OF INHIBITION OF GASTRIC ACID SECRETION BY PANTOPRAZOLE
泮托拉唑抑制胃酸分泌的关键功效研究
批准号：
6279657
负责人：
JOSEPH R PISEGNA
金额：
$1.77万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6279657
关键词：
Zollinger Ellison syndrome antiulcer drug benzimidazoles clinical research clinical trials drug screening /evaluation endocrine neoplasm gastric acid gastric juice inhibitor gastrointestinal disorder chemotherapy human subject human therapy evaluation intravenous administration secretion stomach surgery

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中文摘要
翻译
目的是确定静脉（IV）给药方案 给予泮托拉唑， 在Zollinger-Ellison患者中，分泌量低于10 mEq/hr 综合征（ZES）伴或不伴多发性内分泌肿瘤-I型（MEN- I）未接受胃部分切除术且小于 5 mEq/hr的ZES伴或不伴MEN-I患者， 接受了部分胃切除术，安全性较低。
英文摘要
The objective is to identify the regimens of intravenously (IV) administered pantoprazole that would decrease and maintain acid secretion at less than 10mEq/hr in patients with Zollinger-Ellison syndrome (ZES) with or without multiple endocrine neoplasia-type I (MEN- I) syndrome who have not undergone partial gastrectomy and at less than 5 mEq/hr in those patients with ZES with or without MEN-I who have undergone partial gastrectomy and to minor safety.
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