MAGNESIUM THERAPY IN SICKLE CELL DISEASE

镰刀状血红蛋白聚合在临床上的结果 镰状细胞病的表现。细胞脱水是由 由聚合的镰状细胞血红蛋白引起的反复镰状 被认为在血管闭塞过程中起主要作用。镁罐头 抑制红细胞脱水，在镰刀细胞转基因小鼠模型中， 高镁饮食使致密细胞减少。初步结果来自 参加这项试验的患者表明，尽管在 血镁水平在患者密集叫声中有所下降 在治疗结束时被记录下来。因为这一延迟是对 镁患者将接受镁治疗的时间长短 将增加，并且在没有的情况下将进一步增加剂量 高镁血症的毒性。

The polymerization of sickle hemoglobin results in the clinical manifestations of sickle cell disease. Dehydrated cells result from repeated sickling caused by the polymerized sickle cell hemoglobin and are thought to play a major role in vaso-occlusive process. Magnesium can inhibit RBC dehydration and in a sickle cell transgenic mouse model, a high magnesium diet decreased dense cells. Preliminary results from patients enrolled in this trial indicate that despite little change in blood magnesium levels some decrease in the patients' dense calls have been noted by the end of therapy. Because of this delay in response to magnesium the length of time patients will be treated with magnesium will be increased and the dosage will be increased further in the absence of toxicity of hypermagnesemia.