CORRELATION BETWEEN QUANTITY OF ALVEOLAR EPITHELIAL CELL SPECIFIC ANTIGENS

加州大学旧金山分校需要气管的新生儿的前瞻性观察研究 在出生后24小时内插管以量化肺泡量 气管分泌物中的I型上皮细胞特异性抗原，以及 描述这些抗原水平随时间的变化。这些级别 并且变化间隔的模式将关联到以下程度 肺损伤的临床评估和长期结局变量，如 慢性肺病。假说是肺损伤的过程 将以I型细胞脱落增加为标志。

A prospective observational study of neonates at UCSF requiring tracheal intubation within 24 hours of birth to quantify the amount of alveolar type I epithelial cell specific antigens in tracheal secretions, and to characterize the changes in these antigen levels over time. These levels and the pattern of change intervals will be correlated to the extent of lung injury assessed clinically and to long term outcome variables such as chronic lung disease. The hypothesis is that the process of lung injury will be marked by increased shedding of type I cells.