FEASIBILITY OF IMAGING HYPERPOLARIZED 129XE

有了光学泵浦机制，大量的核子 自旋超极化的惰性气体可以储存和积累 未来的应用。事实已经证明，这些都是强有力的 极化气体可能在医学成像中有用。我们正在探索 利用吸收自旋超极化~(129)Xe(Xe)的可行性 作为麻醉剂)在医学成像中。第一，北京129Xe的T1‘S 生物体液将被测量；因为短T1是明显的 使用自旋超极化信号源的限制因素。第二, 我们将核实我们能够生产足够数量的 自旋超极化的129Xe第三，Xe转移到 想象力学科将得到发展。最终，我们将想象Xe 在NMRFAM的小口径成像系统中被老鼠吸入使用 23Na成像探头。由于增加了磁化强度， 超极化、信噪比(S/N)应为ON 目前医用~1H成像的S/N顺序 申请。吸入的Xe气体会扩散到全身， 为1H成像提供了一个有趣的补充。Xe的核磁共振性质 (化学位移和关系时间)在很大范围内变化 不同的生物环境，从而获得有趣的图像 对比度。自旋超极化129Xe成像的可能应用 包括：肺空域成像；肺组织成像；脑血 流量测量；蛋白质示踪研究；以及探查麻醉剂 行动。

With optical pumping mechanisms, large amounts of nuclear spin-hyperpolarized noble gases can be stored and accumulated for future applications. It has been demonstrated that these strongly polarized gases may be useful in medical imaging. We are exploring the feasibility of using absorbed, spin-hyperpolarized, 129Xe (Xe acts as an anesthetic) in medical imaging. First, T1's of 129Xe in biological fluids will be measured; as a short T1 is an obvious limiting factor in using spin-hyperpolarized signal sources. Second, we will verify that we can produce adequate amount of spin-hyperpolarized 129Xe. Third, a mechanism for Xe transfer to the imagining subject will be developed. Eventually, we will image Xe inhaled by a mouse in the NMRFAM's small-bore imaging system using the 23Na imaging probe. Because of the increased magnetization gained by the hyperpolarization, the signal-to-noise ratio (S/N) should be on the order of the S/N of 1H imaging currently performed in medical applications. Inhaled Xe gas will diffuse throughout the body and provide an interesting compliment to 1H imaging. Xe's NMR properties (chemical shift, and relation times) vary over a large range in different biological environments thus allowing for interesting image contrast. Possible applications for spin-hyperpolarized 129Xe imaging include: lung airspace imaging; lung tissue imaging; cerebral blood flow measurements; protein tracer studies; and probing anesthetic action.