EFFECT OF IGF-1 ON MALNOURISHED CHILDREN WITH CYSTIC FIBROSIS

我们的目标是确定用胰岛素样生长因子治疗 胰岛素样生长因子(IGF-I)改善营养不良者的营养状况并促进生长 患有囊性纤维化的儿童。我们正处于1-2期双打中 一项盲法交叉研究，将IGF-I与安慰剂治疗进行比较 营养不良的CF患者。营养不良对生存有不利影响 在肺功能恶化的CF患者中很常见 功能。营养补充剂通常需要使用 胃造口术或鼻胃管。然而，喂养是困难的 管理并可能进一步污蔑患有CF的儿童和青少年。 血中胰岛素样生长因子-I的水平，这是一种生长促进肽，是 正常生长，在患有CF的儿童和青少年中都很低。自.以来 IGF-I治疗改善营养不良患者的营养状况 患者，评估促生长治疗是有道理的 营养不良的CF患儿体内的多肽。此外， IGF-I有助于调节血糖水平。胰岛素样生长因子-I对血液的影响 血糖控制可能特别重要，因为CF患者 患糖尿病的风险增加。如果IGF-I改善营养状况 状态、生长和血糖控制，那么它可能会增强 营养不良的CF儿童的功能结局。

Our goal is to determine if treatment with insulin-like growth factor (IGF-I) improves nutritional status and promotes growth in undernourished children with cystic fibrosis. We are in the midst of a phase 1-2 double blind crossover study that compares the treatment with IGF-I to placebo in undernourished patients with CF. Malnutrition adversely affects survival and is prevalent among patients with CF who have deteriorating pulmonary function. Nutritional supplementation often requires the use of a gastrostomy or nasogastric tube. However, the feedings are difficult to administer and may further stigmatize children and adolescents with CF. Blood levels of IGF-I, a growth-promoting peptide that is necessary for normal growth, are low in children and adolescents with CF. Since treatment with IGF-I improves nutritional status in undernourished patients, a rationale exists to assess treatment with growth-promoting peptides in those children with CF who are undernourished. Furthermore, IGF-I helps to regulate blood sugar levels. The effect of IGF-I on blood glucose control may be of particular importance since patients with CF have an increased risk to develop diabetes. If IGF-I improves nutritional status, growth, and glucose control, then it will likely enhance functional outcome in undernourished children with CF.