ANALYSIS AND PHYSIOLOGY OF ISOFLAVONES IN SOYBEANS

这项研究专门针对确定在人类身上， 非甾体异黄酮类药物的生物利用度和药代动力学 富含在大豆食品和配方中的雌激素化合物。 这些具有生物活性的非营养素的新陈代谢已经被广泛地 在动物身上研究，但在人类身上的信息有限。虽然我们 之前已经建立了一个饮食摄入量水平，可以引发 女性的生物反应，对其生物利用度知之甚少 来自不同食物或配方的异黄酮类，无论是大的 个体之间的差异，或与性别或年龄相关的差异 吸收或新陈代谢，以及是否有剂量反应效应。对这件事 最后，我们将测定其生物利用度和药代动力学。 不同种类的食物和配方中所含的大豆异黄酮。

This study is specifically directed at determining in humans, the bioavailability and pharmacokinetics of isoflavones, non-steroidal estrogenic compounds, contained in abundance in soy foods and formulas. The metabolism of these bioactive non-nutrients has been extensively studied in animals, but information in humans is limited. Although we have previously established a level of dietary intake that can invoke a biological response in women, little is known about the bioavailability of isoflavones from different foods or formulas, whether there are large variations among individuals, or gender or age-related differences in absorption or metabolism, and if there are dose-response effects. To this end, we will be determining the bioavailability and pharmacokinetics of soy isoflavones contained in different kinds of foods and formulas.