GOG 162--PHASE III RANDOMIZED TRIAL OF CISPLATIN AND PACLITAXEL--OVARIAN CANCER

GOG 162：这个协议将检查安全地给两个人的最好方法 化疗药物顺铂和紫杉醇治疗晚期肺癌 卵巢癌。大约5-10名患者将在当地招募。 患者将被随机分配接受化疗药物紫杉醇 超过24小时或超过96小时，然后是药物顺铂。这个 给紫杉醇的标准方法是缓慢地将其注入静脉 24小时，但有一些证据表明，稍微低一点的剂量 经过更长的时间可能会更有效。化疗将会 每3周重复一次，共6个周期，除非有 过度的副作用或肿瘤正在生长。

GOG 162: This protocol will examine the best way to safely give the two chemotherapy drugs cisplatin and taxol to treat subjects with advanced ovarian cancer. Approximately 5-10 patients will be enrolled locally. Patients will be randomly assigned to receive the chemotherapy drug Taxol over 24 hours or over 96 hours followed by the drug cisplatin. The standard method of giving Taxol is to inject it into a vein slowly over 24 hours, but there is some evidence that giving a slightly lower dose over a longer time may be more effective. Chemotherapy treatments will be repeated every 3 weeks for a total of 6 cycles unless there are excessive side effects or tumor is growing.