GOG 114--IV CISPLATIN AND TAXOL VS HIGH DOSE IV CARBOPLATIN IN OVARIAN CANCER

GOG 114--IV 顺铂和紫杉醇与高剂量 IV 卡铂在卵巢癌中的比较

• 批准号: 5224983
• 负责人: PATRICIA S BRALY
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5224983
• 关键词: cis platinum compound; clinical research; clinical trials; cooperative study; cyclophosphamide; female; female reproductive system surgery; human subject; human therapy evaluation; intravenous administration; neoplasm /cancer chemotherapy; ovary neoplasms; paclitaxel

This study is a nation-wide cooperative group study investigating whether Cyclophosphamide or Taxol is more effective when added to Cisplatin chemotherapy or whether giving two cycles of a related drug, Carboplatin, followed by Taxol by vein and Cisplatin into the abdominal cavity is more effective in subjects with advanced ovarian cancer. Following the chemotherapy regimen (6 cycles), a second surgery (second look laparatomy) is recommended to determine if the cancer has been eliminated.

这项研究是一项全国性的合作小组研究，旨在调查 环磷酰胺或紫杉醇与顺铂联用时更有效 化疗或给予两个周期的相关药物，卡铂， 其次是紫杉醇经静脉和顺铂进入腹腔较多。 对晚期卵巢癌患者有效。紧随其后的是 化疗方案(6个周期)，第二次手术(第二次检查 建议进行腹腔镜术)以确定癌症是否已经 被淘汰了。