LATE EFFECTS OF CANCER TREATMENT

对接受放射治疗和化疗的癌症长期幸存者的研究导致了对癌症发生的重要见解。与医学科合作，我们扩大了对小细胞肺癌后的第二种癌症的研究，以评估筛查和随访的几个临床参数。我们还在更新幸存者的数据，以完善风险估计。与辐射流行病学分会合作，我们已经启动了一项针对视网膜母细胞瘤幸存者的研究，这些幸存者已经发展成黑色素瘤。我们正在检查幸存者和他们的一级亲属，以及视网膜母细胞瘤和黑色素瘤患者的一级亲属。有关视网膜母细胞瘤治疗的信息已经可用，但我们还将获得阳光、烟草和酒精暴露的信息。我们继续在儿童时期接受头部和颈部照射的一群人中进行与辐射相关的神经肿瘤的实地研究。我们计划为这项研究增加多达40名患有头颈部神经肿瘤的队列成员。-人类受试者和人类受试者：18岁以下未成年人和人类受试者：仅限采访、问卷或调查

Studies of long-term survivors of cancer treated with radiation therapy and chemotherapy have led to important insights into carcinogenesis. In collaboration with the Medicine Branch, we have extended the study of second cancers after small cell lung cancer to evaluate several of the clinical parameters of screening and followup. We are also updating the data for the survivors to refine the risk estimates. In collaboration with the Radiation Epidemiology Branch, we have initiated a study of survivors of retinoblastoma who have developed melanoma. We are examining survivors and their first degree relatives and first degree relatives of individuals with retinoblastoma and melanoma who are deceased. Information on treatment for the retinoblastoma is already available, but we will also obtain sun, tobacco, and alcohol exposure information. We have continued the field work for the study of radiation-related neural tumors in a cohort of individuals who received head and neck irradiation in childhood. We plan to add up to 40 additional cohort members to the study who have developed head and neck neural tumors. - Human Subjects & Human Subjects: Minor under 18 Years Old & Human Subjects: Interview, Questionaires, or Surveys Only