CHARACTERIZATION OF NON-PROTEIN COLLOIDAL PLASMA VOLUME EXPANDERS

在截至1999年9月30日的报告年度内，没有就该项目开展任何工作。 我们目前正在探索Wyatt Technology，Corp.使用其多角度激光散射-SE-HPLC（MALLS-SE-HPLC）装置测定右旋糖酐70、右旋糖酐40和羟乙基淀粉样品的重均和数均分子量的可能性。 结果将允许Wyatt值与我们先前使用静态激光散射和膜渗透压测定法分别测定重均分子量和数均分子量的Wyatt值进行比较，从而允许评估Wyatt装置/方法用于这些产品的商业表征的适当性。

During the reporting year ending September 30, 1999, no work was performed on this project. We are currently exploring the possiblity of having the weight and number average molecular weights determined for samples of Dextran 70, Dextran 40, and Hetastarch by Wyatt Technology, Corp. using their multi-angle laser light scattering-SE-HPLC (MALLS-SE-HPLC) apparatus. The results will permit a comparison of the Wyatt values with those that were determined by us previously using static laser light scattering and membrane osmometry for weight and number average molecular weights, respectively, thereby allowing an assessment of the appropriateness of the Wyatt apparatus/methodology for commercial characterization of these products.