COMPUTER ANALYSIS OF SEQUENCES FROM MICROORGANISMS

计算机分析，包括应用几种新的算法，已与实验室密切合作进行，并已开发新的计算策略，以应对有关感兴趣的蛋白质的结构，功能，相互作用和遗传学的问题。几种重要的寄生虫和病原体，包括疟疾寄生虫恶性疟原虫，在基因和蛋白质的残留成分中显示出极端的偏差。这些组成特性，连同低复杂性，nongolobular和构象移动的部分的蛋白质的作用的问题，是相关的方面，这些生物体的致病性和它们与哺乳动物宿主的相互作用，与疫苗设计的应用程序和耐药性的新见解的发展。- 计算机算法、蛋白质序列、基因组序列、寄生虫、细菌、古生菌、成分偏差

Computer analysis, including application of several new algorithms, have been carried out in close collaboration with experimental laboratories, and new computational strategies have been developed in response to questions arising about the structures, functions, interactions and genetics of the proteins of interest. Several important parasites and pathogens, including the malaria parasite Plasmodium falciparum, show extreme bias in the residue compositions of both genes and proteins. These compositional properties, together with questions about the roles of low-complexity, nonglobular and conformationally mobile parts of proteins, are relevant to aspects of the pathogenicity of these organisms and their interactions with the mammalian hosts, with applications to vaccine design and the development of new insights into drug resistance. - Computer algorithms, protein sequences, genome sequences, parasites, bacteria, archaea, compositional bias