Contribution of Vasoactive Prostanoids to Vascular Tone

内皮通过释放不同的因子调节血管稳态，包括血管活性前列腺素。这些物质可以调节血管张力和其他血管过程。本研究的目的是评估血管活性前列腺素类对正常人血管张力的贡献，并确定这种调节活性在与过早动脉粥样硬化相关的疾病中是否功能失调，如原发性高血压和高胆固醇血症。为此，我们研究了增加阿司匹林剂量对环氧合酶抑制的影响。（阿萨;以1、3和10 mg/min输注，每次给药10 min）对10名健康受试者静息血管张力的影响（年龄：49+/-7岁，6男4女），9例高血压（年龄：51+/-5岁，5名男性和4名女性）和10名高胆固醇血症患者（年龄：54+/-4岁，7名男性和3名女性）。阿萨注入肱动脉，通过应变计体积描记术测量前臂血流量（FBF）（值=平均值+/-sd）。在最高剂量下，阿萨使健康受试者的静息FBF从2.8+/-0.9降至2.3+/-0.7 ml/min/dl（p=0.04）;高血压患者从2.9+/-0.9至2.3+/-0.8 ml/min/dl（p=0.05）;高胆固醇血症患者从3.0+/-0.6至2.2+/-0.6 ml/min/dl（p<0.0001）。阿萨的血流动力学效应在健康受试者、高血压或高胆固醇血症患者之间没有差异（FBF减少：14+/-28%，14？28%和27+/-14%; p=0.40）。这些发现表明，来自环氧合酶代谢的血管扩张剂前列腺素类在维持人类静息微血管张力中发挥作用。这一生理过程在原发性高血压或高胆固醇血症患者中似乎没有改变。- 前列腺素类高血压高胆固醇血症血管-人类受试者

The endothelium modulates vascular homeostasis through the release of different factors, including vasoactive prostanoids. These substances may regulate vascular tone and other vascular processes. The aims of this study were to assess the contribution of vasoactive prostanoids to vascular tone in normal humans and to determine whether this regulatory activity is dysfunctional in conditions associated with premature atherosclerosis, such as essential hypertension and hypercholesterolemia. To this end, we investigated the effect of cyclooxygenase inhibition with increasing doses of aspirin (ASA; infused at 1, 3, and 10 mg/min, each dose for 10 min) on resting vascular tone in 10 healthy subjects (age: 49+/-7 years, 6 men and 4 women), 9 hypertensive (age: 51+/-5 years, 5 men and 4 women), and 10 hypercholesterolemic patients (age: 54+/-4 years, 7 men and 3 women). ASA was infused into the brachial artery, and forearm blood flow (FBF) was measured by strain gauge plethysmography (values=mean+/-sd). At the highest dose, ASA decreased resting FBF in healthy subjects from 2.8+/- 0.9 to 2.3+/-0.7 ml/min/dl (p=0.04); in hypertensive patients from 2.9+/-0.9 to 2.3+/-0.8 ml/min/dl (p=0.05); and in hypercholesterolemic patients from 3.0+/-0.6 to 2.2+/-0.6 ml/min/dl (p<0.0001). The hemodynamic effect of ASA was not different between healthy subjects, and hypertensive or hypercholesterolemic patients (reduction in FBF: 14+/-28%, 14?28%, and 27+/-14%, respectively; p=0.40). These findings suggest that vasodilator prostanoids derived from cyclooxygenase metabolism play a role in the maintenance of resting microvascular tone in humans. This physiologic process does not seem to be altered in patients with essential hypertension or in those with hypercholesterolemia. - prostanoids hypertension hypercholesterolemia blood vessels - Human Subjects