Enhanced Membranes for Active Mixing Oxygenators

历史上用于短期旁路手术或新开发的长期策略的血液氧合器使用的系统是液体侧传质，有限的。长期治疗需要无孔涂层来限制血液氧合器的湿化。设计上的进步改善了流体动力学，从而增强了传质。在这些后期系统中，膜运输的限制现在是主要的限制。紧凑型膜系统（CMS）开发了用于长期血液氧合的无孔膜。CMS第一代血氧技术生产的膜具有150cc /min-m2的氧运输能力。随着第二代系统更加紧凑，需要更高通量的无孔膜。CMS已经确定了新的途径，提高膜氧运输十倍。这种氧传输的改进应该足以满足改进的流体动力学第二代产品的需要。这些新系统还将显著提高制造经济性。在第一阶段，CMS将开发用于血液氧合的膜，通量提高五倍。这些新型膜将改善流体动力学，显著提高系统的整体性能。动物研究与详细的方法包括在这个程序。在测试结束时，将验证膜的完整性。建议的商业应用：该技术将广泛增强长期和短期血气交换的能力。因此，对于ARDS、ECMO、人工肺以及常规旁路手术的长期治疗具有一定的价值。

Historically blood oxygenators for short-term by-pass surgery or newly developing long-term strategies use systems that are liquid side mass transfer, limited. Long-term therapies require non-porous coatings to limit blood oxygenator wet out. Design advances led to improved fluid dynamics which enhanced mass transfer. In these later systems membrane transport limitations now are major limitations. Compact Membrane Systems (CMS) developed non-porous membranes for long-term blood oxygenation. This CMS first generation blood oxygenation technology produces membranes with 150 cc/min-m2 oxygen transport. With more compact second generation systems there is need for higher flux non-porous membranes. CMS has identified novel routes to improve membrane oxygen transport ten-fold. This improvement in oxygen transport should be sufficient to meet need of improved fluid dynamics second generation products. These new systems should also significantly improve fabrication economics. In Phase I CMS will develop membranes for blood oxygenation with a five-fold improvement in flux. These novel membranes will demonstrate improved fluid dynamics and significantly enhance overall system performance. Animal studies with detailed methodology are included in this program. Membrane integrity will be verified at the end of the tests. PROPOSED COMMERCIAL APPLICATIONS: This technology will broadly enhance the capability for both long-term and short-term blood gas exchange. Therefore it should be of value for long-term treatments for ARDS, ECMO and artificial lung as well as conventional by-pass surgery.