Biodegradable Scaffolds for Periodontal Void-Filling

描述：在牙周嵴重建和随后的种植 固定，挑战在于用移植材料填充骨空隙， 保持移植区域的体积和形状，并支撑结构 在整个新骨再生过程中保持该部位的完整性。的 这项拨款申请的目的是采用生物聚合物支架， 改善自体移植骨的成型、处理和机械性能 通过增强其骨诱导性和保持牙槽嵴形状的能力， 重建后的体积。虽然自体骨移植是骨的金标准 自体移植修复牙周组织缺损的效果 重建有时是不可预测的， 而且音量也不小。该申请假定， 可降解的生物聚合物支架将至少实质性地延伸自体移植物 而不损害其骨诱导性质， 作为移植物的移植物材料的机械和生物活性特性 合并发生。因此，第一阶段项目将调查 增强组织反应和维持机械 完整性，牙周缺损修复或空隙填充使用 生物聚合物支架，采用体外机械和体内组织学 和组织形态学结果。 拟定商业应用： 骨是仅次于血液的第二大植入材料。 有超过 美国每年进行45万例骨移植手术（全球220万例）。 这些植入物的市场潜力为4亿至6亿美元。 新型组织工程 骨替代材料，包括应用于牙周应用的那些， 在不断增长的市场中找到利基。

DESCRIPTION: In periodontal ridge reconstruction and subsequent implant fixation, the challenge is to fill bony voids with a graft material, which will maintain the volume and shape of the grafted area and support the structural integrity of the site throughout the course of new bone regeneration. The objective of this grant application is to employ biopolymer scaffolds to improve upon the molding, handling, and mechanical properties of autograft bone by augmenting its osteoinductivity and ability to maintain ridge shape and volume after reconstruction. Although autograft is the gold standard of bone transplantation, the results of autograft reconstruction in periodontal ridge reconstruction are sometimes unpredictable and loss of reconstructive height and volume is not infrequent. The application posits that the use of a degradable biopolymeric scaffold will at least materially extend an autograft without compromising its osteoinductive properties and at best improve upon both the mechanical and bioactivity properties of the graft material as graft consolidation occurs. Therefore, this Phase I project will investigate the feasibility of enhancing tissue responses in, and maintaining the mechanical integrity of, periodontal defects subject to repair or void filling using a biopolymeric scaffold by employing in vitro mechanical and in vivo histologic and histomorphometric outcomes. PROPOSED COMMERCIAL APPLICATION: Bone is the second most implanted material in the body after blood. There are more than 450,000 bone graft procedures proformed annually in the U.S. (2.2 million worldwide). The market potential for these implants is $400 to $600 million. New tissue engineered bone replacement materials, including those applied to periodontal applications, would find a niche in the ever-growing market.