ANALYSIS AND PHYSIOLOGY OF ISOFLAVONES IN SOYBEANS

这项研究是专门针对确定在人类中，生物利用度和药代动力学的非甾体雌激素化合物，丰富的大豆食品和配方。这些生物活性非营养素的代谢已在动物中进行了广泛研究，但人类的信息有限。 虽然我们以前已经建立了一个饮食摄入水平，可以引起女性的生物反应，但对不同食物或配方中的胆甾酮的生物利用度知之甚少，个体之间是否存在很大的差异，或者性别或年龄相关的吸收或代谢差异，以及是否存在剂量反应效应。 为此，我们将确定不同种类的食品和配方中含有的大豆异黄酮的生物利用度和药代动力学。

This study is specifically directed at determining in humans, the bioavailability and pharmacokinetics of isoflavones, non-steroidal estrogenic compounds, contained in abundance in soy foods and formulas. The metabolism of these bioactive non-nutrients has been extensively studied in animals, but information in humans is limited. Although we have previously established a level of dietary intake that can invoke a biological response in women, little is known about the bioavailability of isoflavones from different foods or formulas, whether there are large variations among individuals, or gender or age-related differences in absorption or metabolism, and if there are dose-response effects. To this end, we will be determining the bioavailability and pharmacokinetics of soy isoflavones contained in different kinds of foods and formulas.