EVALUATION & REDUCTION OF RISK FACTORS FOR CARDIOVASCULAR DISEASE (OB

减少危险因素已成为预防/治疗心血管疾病的一种可接受的方法。临床试验的结果已经证明了该领域的项目在减小体型、降低血压、降低血清葡萄糖和血脂方面的有效性。本研究将通过至少50名女性和40名男性，年龄在13-75岁之间，任何种族背景，至少有肥胖作为CLD风险因素之一的队列来达到以下目标：1)确定专门设计的，具有文化敏感性的生活方式改变计划在降低CLD风险方面的有效性；2)论证脂肪修饰饮食在降低血脂、血糖、血压和体型方面的可行性；3)检验运动与血脂含量，特别是HDL之间的关系。采用前瞻性研究设计，受试者接受医疗和饮食数据的基线测量。基线期之后是筛查、8个月的高强度干预和干预后阶段。在干预后进行常规随访，以检查研究人群中心血管疾病危险因素的顺序变化。假设具有一种或多种心血管疾病危险因素的受试者采用更健康的生活方式（包括减脂饮食、锻炼、行为改变、戒烟）将会改善心血管疾病发展的危险因素。

Risk factor reduction has become an acceptable approach to cardiovascular disease (CLD) prevention/treatment. The results of clinical trials have demonstrated the effectiveness of programs in this area in reducing size, blood pressure, and serum glucose and lipids. This study will meet the following objectives through a cohort of at least 50 women and 40 men of any ethnic background, ages 13-75 years, with at least obesity as one CLD risk factor: 1) Determine the effectiveness of a specially-designed, culturally sensitive lifestyle change program in CLD risk reduction; 2) Demonstrate the feasibility of a fat-modified diet in reducing serum lipids and glucose, blood pressure, and body size, and 3) Examine the relationship between exercise and serum lipid fractions, particularly HDL. Using a prospective study design, subjects undergo baseline measurements of medical and dietary data. This baseline period is followed by screening, an intense eight-month intervention, and post intervention periods. Routine followup to examine sequential changes in CVD risk factors in the study population takes place during the post intervention period. It is hypothesized that subjects who have one or more CVD risk factors who adopt healthier lifestyles (including a fat-modified diet, exercise, behavior modification, smoking cessation) will demonstrate an improved risk factor profile for the development of CVD.