AASK-CO

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。AASK队列研究是一项前瞻性、观察性研究，是AASK临床试验的延伸。AASK试验是一项随机临床试验，测试了用作一线高血压治疗的3种不同药物（雷米普利、美托洛尔和曲马多）和2种水平的血压控制（常规和更积极的控制）的效果。在AASK的1，094名随机参与者中，估计霍华德大学将在AASK队列研究中招募29名（在AASK临床试验中未达到ESRD的657-750名个体中）。此外，那些到达ESRD的AASK参与者将被邀请参加一次DNA采集访视。AASK队列研究中每年收集两次的暴露量包括环境、遗传、生理和社会经济因素。主要肾脏结局将是定义为血清肌酐加倍、进展为ESRD或死亡的临床结局。将向所有未患有ESRD的受试者提供适当的降压治疗（药物和目标BP水平，由AASK试验确定）。以这种方式，队列将直接控制肾脏疾病进展的两个主要“已知”决定因素（治疗高血压和使用肾脏保护性降压药物），因此，将在推荐的高血压治疗环境中解决其研究目标。预计每名受试者每年将进行最少4次、最多6次BP控制联系。队列研究的预期随访持续时间为5年（包括AASK试验在内，共计9-12年），AASK队列研究将提供数据，增强我们对决定肾脏疾病进展的过程的理解。此外，这项研究的数据可能最终导致延迟或预防ESRD发作的新预防策略。 尽管血压控制良好，并使用肾脏保护性降压药物，高血压相关肾脏疾病通常进展。AASK队列研究的主要目的是前瞻性确定接受推荐降压治疗的高血压相关肾病非裔美国人的肾功能长期病程和肾脏疾病进展的风险因素。次要目的是确定心血管疾病的发生率，并评估其在高血压相关肾脏疾病背景下的危险因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The AASK Cohort Study is a prospective, observational study that is an extension of the AASK Clinical trial. The AASK trial was a randomized, clinical trial that tested the effects of 3 different medications used as first line hypertensive therapy (ramipril, metoprolol and amlodipine) and 2 levels of BP control (usual and more aggressive control). Of the 1,094 randomized participants in AASK, it is estimated that Howard University will enroll 29 (of the 657-750 individuals who did not reach ESRD in the AASK Clinical Trial) in the AASK Cohort Study. Additionally, those AASK participants who reached ESRD will be invited to attend one visit for collection of DNA. Exposures to be collected twice/year for those in the AASK Cohort Study include environmental, genetic, physiologic and socioeconomic factors. The primary renal outcome will be a clinical outcome defined by the doubling of serum creatinine, progression to ESRD or death. Appropriate antihypertensive treatment (medications and target BP levels as determined by the AASK trial) will be provided to all participants who do not have ESRD. In this fashion, the Cohort will directly control two of the major "known" determinants of kidney disease progression (treatment of hypertension and use of reno-protective, antihypertensive medications) and will, therefore, address its research objectives in the setting of recommended hypertensive care. It is anticipated that a minimum of 4 and a maximum of 6 contacts for BP control will take place per year for each participant. The anticipated duration of followup in the Cohort Study will be 5 years (total of 9-12 years, including the AASK Trial), and that the AASK Cohort Study will provide data that enhances our understanding of the processes that determine progression of renal disease. Furthermore, data from this study might ultimately lead to new prevention strategies that delay or prevent the onset of ESRD. Despite excellent BP control and use of reno-protective antihypertensive medication, hypertension-related renal disease commonly progresses. The primary objective of the AASK Cohort Study is to prospectively determine the long-term course of kidney function and risk factors for kidney disease progression in African Americans with hypertension-related kidney disease who receive recommended antihypertension therapy. A secondary objective is to determine the occurrence of cardiovascular disease and assess its risk factors in the setting of hypertension-related kidney disease.