ACUTE DRUG EFFECTS ON SIMPLE AND COMPLEX PERFORMANCE SUBSTUDY D

我们将调查四种经常滥用的物质的影响 （大麻，咖啡因，阿普唑仑和酒精） 性能这些药物的不同剂量与安慰剂的比较 将采用一系列双盲交叉实验。咖啡因 还将研究戒断效应。虽然一系列的数据 任务是要收集，重点放在性能在一个独特的 提供验证信息的实验模拟设置 从事白色领职业。拟议的研究是 设计1。研究药物使用和滥用的影响 （大麻，咖啡因，阿普唑仑和酒精）的各个方面， 白色领任务表现，2.来阐明可能的关系 血液水平和复杂性能之间的关系，3.确定 物质剂量对复杂任务绩效的影响，4.以确定 物质戒断对任务绩效的影响，5。以确定 物质对更简单的生物体的影响 以及更复杂的性能方面。第三刺激 将（根据需要）修改并验证方案，以提供 更有效的治疗内比较（例如，两种药物水平与 第1至5项（如适用）研究中的安慰剂）条件。

We will investigate the impact of four frequently abused substances (marijuana, caffeine, alprazolam and alcohol) on work related performance. Comparisons of diverse dosages of these drugs with placebo will employ a series of double-blind cross-over experiments. Caffeine withdrawal effects will also be investigated. While data on a range of tasks are to be collected, emphasis is placed on performance in a unique experimental simulation setting that provides validated information on functioning in white collar occupations. The proposed research is designed 1. to examine the effects of substance use and abuse (marijuana, caffeine, alprazolam and alcohol) on various aspects of white collar task performance, 2. to elucidate possible relationships between blood levels and complex performance, 3. to determine the effects of substance dosage on complex task performance, 4. to determine the effects of substance withdrawal on task performance, 5. to determine the extent to which parallels in the effects of substances on simpler and on more complex aspects of performance exist. A third stimulation scenario will be modified (as needed) and validated to provide for more efficient comparison of within treatment (e.g., two drug levels vs. placebo) conditions in research on items 1 through 5 as applicable.