NALTREXONE AND ALPRAZOLAM-INDUCED FMRI CHANGES

纳曲酮和阿普唑仑引起的 FMRI 变化

• 批准号: 7379477
• 负责人: Chris Conway Streeter
• 金额: $ 0.69万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379477
• 关键词: NALTREXONE; ALPRAZOLAM; INDUCED; FMRI; CHANGES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Alcoholism is a multifactorial disorder associated with tremendous individual disability and enormous cost to society. Naltrexone is an opioid blocker recently approved for the treatment of alcoholism. Increased understanding of the neurobiologic effects of naltrexone is needed to maximize the effective use of this drug and to plan for new pharmacologic treatments. The mood enhancing effects of a benzodiazepine challenge can serve as a probe to study the effects of naltrexone on alcohol-induced mood enhancement and cerebral function.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。酒精中毒是一种多因素的疾病，与巨大的个人残疾和巨大的社会成本有关。纳洛酮是一种阿片类药物阻滞剂，最近被批准用于治疗酒精中毒。需要增加对纳洛酮的神经生物学作用的理解，以最大限度地有效利用这种药物，并计划新的药理学治疗。苯二氮卓类药物激发的情绪增强效应可以作为研究纳洛酮对酒精诱导的情绪增强和脑功能影响的探针。