NALTREXONE AND ALPRAZOLAM-INDUCED FMRI CHANGES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。酒精中毒是一种多因素的障碍，与巨大的个人残疾和巨大的社会成本有关。纳曲酮是一种阿片类阻滞剂，最近被批准用于治疗酒精中毒。需要更多地了解纳曲酮的神经生物学效应，以最大限度地有效使用该药物，并计划新的药物治疗。苯二氮卓类刺激的情绪增强效应可作为研究纳曲酮对酒精诱导的情绪增强和脑功能影响的探针。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Alcoholism is a multifactorial disorder associated with tremendous individual disability and enormous cost to society. Naltrexone is an opioid blocker recently approved for the treatment of alcoholism. Increased understanding of the neurobiologic effects of naltrexone is needed to maximize the effective use of this drug and to plan for new pharmacologic treatments. The mood enhancing effects of a benzodiazepine challenge can serve as a probe to study the effects of naltrexone on alcohol-induced mood enhancement and cerebral function.