BEHAVIORAL AND REINFORCING EFFECTS OF ALPRAZOLAM IN MONKEYS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Benzodiazepines (BZs) are clinically effective as sedatives and anxiolytics; however, unwanted side effects can limit their usefulness. We examined the relationship among the sedative and abuse-related effects of the conventional BZ alprazolam in rhesus monkeys. The minimally effective doses (MEDs) of alprazolam required to engender behavioral signs of sedation and i.v. self-administration were determined in two groups of monkeys. Alprazolam induced sedative effects and maintained self-administration behavior; however, analyses of MEDs indicated sedation occurred at doses higher than the doses required to maintain self-administration.