BEHAVIORAL AND REINFORCING EFFECTS OF ALPRAZOLAM IN MONKEYS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。苯二氮类药物(BZS)作为镇静剂和抗焦虑药在临床上是有效的；然而，不受欢迎的副作用可能会限制它们的用途。我们研究了传统BZ阿普唑仑对恒河猴的镇静作用和滥用相关作用之间的关系。产生镇静和静脉注射行为迹象所需的阿普唑仑最低有效剂量(MEDS)。测定了两组猴子的自我管理能力。阿普唑仑产生镇静作用并维持自我给药行为；然而，对药物的分析表明，镇静发生的剂量高于维持自我给药所需的剂量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Benzodiazepines (BZs) are clinically effective as sedatives and anxiolytics; however, unwanted side effects can limit their usefulness. We examined the relationship among the sedative and abuse-related effects of the conventional BZ alprazolam in rhesus monkeys. The minimally effective doses (MEDs) of alprazolam required to engender behavioral signs of sedation and i.v. self-administration were determined in two groups of monkeys. Alprazolam induced sedative effects and maintained self-administration behavior; however, analyses of MEDs indicated sedation occurred at doses higher than the doses required to maintain self-administration.