MBRS PROGRAM

国家卫生研究所MBRS德克萨斯A&M大学金斯维尔分校的课程包括 主要目标如下：（1）建立并支持一个 在TAMUK适当的生物医学研究环境;（2）吸引，培养 并鼓励学生通过参与研究事业， 六名主要研究人员的研究项目， 提交的研究建议的核心;（3）提供一个合适的 基础设施，允许参与调查人员检查关键 生物医学研究的各个方面（特别是生物和化学方面） （4）提供大量和重要的数据和信息 关于生物医学相关性和重要性的问题。 这六项新计划的范围和用途各有不同， 生物医学问题。第一个问题主要考察 单纯疱疹病毒的转录控制和 病毒潜伏期和再激活。第二个项目将阐明 子宫特异性生长因子对胎儿造血的影响 在细胞分化后。第三个项目包括详细的 果蝇ether-a-go-go相关基因（dERG）的特征 钾通道在转录水平的控制，以及 第二位点修饰物的遗传分离和表征 dERG突变。第四个项目包括对响尾蛇毒液的研究 以及蛇毒金属蛋白酶的功能特性， 新的哺乳动物抗肿瘤素。第五个项目研究生物 生殖状态和能量的节律和调节作用 新陈代谢.第六个项目研究新的酪氨酸激酶介导的 福氏志贺菌中参与并促进 特定病原体的侵袭力 这六个项目支持两个不同部门的研究， 为参与者提供理想的机会，以扩大和 加强个人研究计划。的研究目标 个别调查员也将提供良好的机会， 对本科生和研究生进行关键方面的培训， 生物医学研究以及为未来的职业生涯做好适当的准备 生物医学研究，特别是生物和化学科学。

The N.I.H.-M.B.R.S. program at Texas A&M university-Kingsville consists of the following primary objectives: (1) establish and provide support for an appropriate biomedical research environment at TAMUK; (2) attract, nurture and encourage students to pursue research careers through participation in the research projects of the six principal investigators that comprise the core of the submitted research proposals; (3) provide a suitable infrastructure that permits participant investigators to examine key aspects of biomedical research (in particular the biological and chemical sciences); and 4) provide substantial and significant data and information regarding questions of biomedical relevance and importance. The six new projects are diverse in their scope and application to biomedical questions. The first question primarily examines the transcriptional control of the Herpes simplex virus and the mechanisms of viral latency and reactivation. The second project will elucidate the role of uterine-specific growth factors upon fetal hematopoiesis and effects upon cell differentiation. The third project consists of a detailed characterization of the Drosophila ether-a-go-go related gene (dERG) potassium channel at the levels of transcriptional control as well as genetic isolation and characterization of second-site modifiers of the dERG mutation. The fourth project consists of a study of rattlesnake venom and the functional characterization of snake venom metalloproteinases and novel mammalian antihemorrhaghins. The fifth project examines biological rhythms and the modulatory effects of reproductive status and energy metabolism. The sixth project examines novel tyrosine kinase-mediated signaling pathways in Shigella flexneri that participate and contribute to the invasiveness of that particular pathogen. The six projects support research in two different departments that provide ideal opportunities for the participant faculty to expand and enhance their individual research programs. The research goals of the individual investigators will also provide excellent opportunities for the training of undergraduate and graduate students in key aspects of biomedical research as well as suitable preparation for future careers in biomedical research, particularly in the biological and chemical sciences.