Double blind, randomised controlled trial assessing the efficacy of endothelin-1 receptor antagonism in preventing peri-procedural myonecrosis in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention

虽然冠状动脉疾病的治疗重点主要集中在心脏的大血管上，但小口径血管也可能在心绞痛、心脏病发作和与支架植入术相关的肌肉损伤患者中发挥重要作用。本项目旨在阐明导致这些小血管功能障碍的可能机制。我还希望找到一种治疗策略，可以使小血管问题患者受益，从而改善他们的总体结局。

While the focus in the treatment of coronary artery disease has primarily been on the large vessels in the heart, vessels of small calibre may also play a significant role in patients with angina, heart attack, and muscle injury related to a stenting procedure.This project aims elucidate the possible mechanisms which cause dysfunction in these small vessels. I also hope to find a treatment strategy which may benefit patients with small vessel problems and thus improve their overall outcome.