EFFECTS OF ETHNICITY ON CYTOCHROME P450 IN HLTHY INDIVS USING MIDAZOLAM

这项研究的目的是确定某些药物从体内消除的方式是否存在种族差异。 咪达唑仑是FDA批准的药物，用于在手术或手术前静脉注射镇静和镇静患者。 口服，仍在研究中。在这项研究中，咪达唑仑被用来确定其从体内清除的速度是否在非洲裔美国人和白人之间存在差异。酮康唑是一种用于治疗某些类型的真菌（酵母）感染的药物。 但是，如果同时服用其他药物（如咪达唑仑），酮康唑也可能减少其他药物的消除。本研究还将研究酮康唑如何影响咪达唑仑的消除以及咪达唑仑如何被吸收到体内。

The purpose of this study is to determine if there are ethnic differences in the way certain drugs are eliminated from the body. Midazolam is an FDA-approved drug that is used intravenously to sedate and calm patients prior to procedures or surgery. Used orally, it is still investigational. In this study midazolam is being used to determine if its rate of clearance from the body is different between African-Americans and Caucasians. Ketoconazole is a drug used to treat certain types of fungal (yeast) infections. However, Ketoconazole may also decrease the elimination of other drugs, such as midazolam, if they are taken together. This study will also investigate how ketoconazole affects the elimination of midazolam and how midazolam is absorbed into the body.