DEVELOPMENT OF PLACEBO MARIJUANA CIGARETTES

在过去的几年里，年轻人滥用大麻的情况稳步增加。导致滥用大麻的主要精神活性成分是β-9-四氢大麻酚(THC)。因此，大麻成瘾一直是许多基础和临床研究项目的主题，这些项目旨在了解成瘾过程的机制和与滥用大麻相关的健康危害。大麻滥用的常见形式是吸烟。由于没有天然大麻味道的安慰剂或对照大麻香烟供应，将尝试开发生产没有或最低水平THC的大麻的方法，并生产具有天然味道的安慰剂大麻香烟，以在SBIR第一阶段合同期间进行研究。此外，还将尝试评估生产具有天然风味的不同强度的大麻香烟的可行性。

During the past several years there has been a steady increase in the abuse of marijuana among young adults. The major psychoactive component of marijuana that causes its abuse is delta-9-tetrahydrocannabinol (THC). As a result marijuana addiction has been the subject of a number of basic and clinical research programs directed toward understanding the mechanism of the addictive processes and the health hazard associated with its abuse. The common form of marijuana abuse is by smoking. Due to the non-availability of placebo or control marijuana cigarettes with natural marijuana flavors, attempts will be made to develop methodologies to produce marijuana with no or lowest level of THC, and produce placebo marijuana cigarettes with natural flavors for research during the SBIR Phase I contract. In addition, an attempt will also be made to evaluate the feasibility of producing marijuana cigarettes of different strengths with natural flavors.