GENETICS OF AUTISTIC DISORDER

描述（根据申请人的描述改编）：本项目的目标 该项目的目的是识别自闭症障碍的不同亚型，并绘制出自闭症患者的 基因座生物学或行为差异（神经生物学表型） 在诊断为AD的患者中。对于稳定的差异， 一级亲属来确定该性状是家族性的， 遗传传播模式。然后他们将应用链接， 关联测试，以适当的一系列基因组DNA标记。 授权= P01 HD 354580002 描述（根据申请人的描述改编）：为了进一步 研究自闭症患者的异常神经系统， 为了进行遗传分析，研究人员将进行高- 分辨率三维磁共振成像（MRI）扫描， 儿童AD人群作为后续完整形态测量的基础 个体全脑体积计算分析 亚结构、半球区域和专门方法的应用 大脑皮层定位和分割。

Description (Adapted from applicant's description): The goal of this project is to identify distinct subtypes of autism disorder and to map the loci biological or behavioral differences (neurobiological phenotypes) among patients diagnosed with AD. For stable differences they will study first-degree relatives to establish the trait is familial and to identify genetic patterns of transmission. Then they will apply linkage and association tests to an appropriate series of genome DNA markers. GRANT =P01HD354580002 Description(Adapted from the applicant's description): To further investigate the anomalous neural systems in autistic disorder as a phenotype for genetic analysis, the investigators will perform high- resolution three-dimensional magnetic resonance imaging (MRI) scans in two childhood AD populations as the basis for subsequent complete morphometric analysis for computation of volume of whole brain, individual substructures, hemispheric regions, and application of specialized method of cortical localization and parcellation.