IGE ISOFORMS IN FOOD INDUCED ATOPIC DERMATITIS IN CHILDREN

在过去的一年中，作为GCRC方案的一部分，从其他研究对象获得了献血，以更好地了解ige介导的食物过敏机制，特别是食物诱发的特应性皮炎。作为我们研究的一部分，我们对花生凝集素糖蛋白，花生凝集素（PNA）可能有助于花生过敏等食物过敏的发展的作用特别感兴趣。我们已经能够确定上调PNA与淋巴细胞结合的特定条件，并且我们目前正在完善我们对PNA诱导促过敏细胞因子分泌和/或IgE合成的条件的理解。这项工作的摘要在1999年AAAAI年会上发表。

In the past year, blood donations from additional study subjects have been obtained as part of this GCRC protocol to better understand the IgE-mediated mechanisms of food allergies and, in particular, of food-induced atopic dermatitis. As part of our investigation, we became particularly interested in the role that a peanut lectin glycoprotein, peanut agglutin (PNA), may help in the development of food allergies such as peanut allergy. We have been able to define specific conditions that upregulate PNA binding by lymphocytes, and we are currently refining our understanding of the conditions under which PNA induces pro-allergic cytokine secretion and/or IgE synthesis. An abstract of this work was presented at the 1999 AAAAI Annual Meeting.