INTERPERITONEAL THERAPY WITH CISPLATIN/CARBOPLATIN AND FUDR IN OVARIAN CANCER

iii期和iv期卵巢癌的标准治疗是手术切除，然后静脉注射紫杉醇和铂化合物，80%的患者在第二次检查+手术时停止进展，20%的患者结果为阴性。当检测到残留疾病时，治疗方法就不那么明确了。在初步研究中，腹腔注射氟尿定（IP）和顺铂显示出令人鼓舞的结果。进入的受试者将是那些已经完成卵巢癌一期化疗，但在复诊+手术时腹膜病变bbb10 - 1cm的患者。将放置IP导管。FUdR （3g）给药3天，顺铂（60mg /m2）在第三天给药。（如适用，可在FUdR后立即服用卡铂[500毫升]。）此治疗周期每3周重复一次。只要没有进展或无法忍受的毒性，总治疗时间将包括6个连续周期。治疗后6周和1年或怀疑复发时，将对受试者进行腹部CT扫描和IP对比检查。该方案已扩展到腹腔扩散的胃肠道恶性肿瘤患者。

Standard treatment of stage-III and -IV ovarian cancer has been surgical resection followed by intravenous paclitaxel and a platinum compound, which stops progression in 80% and results in negative findings in 20% of patients at -second-look+ surgery. When residual disease is detected, therapy is less clear. In pilot studies, intraperitoneal (IP) floxuridine (FUdR) and cisplatin showed encouraging results. Subjects to be entered will be those who have completed stage-I chemotherapy for ovarian cancer but at -second-look+ surgery have > 1 cm peritoneal disease. IP catheters will be placed. FUdR (3g) will be given IP for 3 days, and cisplatin (60 mg/m2) will be given IP on the third day. (When applicable, carboplatin [500 ml] may follow immediately after FUdR.) This treatment cycle will be repeated every 3 weeks. Total duration of treatment will consist of 6 consecutive cycles as long as there is no progression or intolerable toxicity. Subjects will be assessed with a CT scan of the abdomen with IP contrast 6 weeks and one year after therapy or whenever recurrence is suspected. This protocol has been extended to patients with Gi malignancies which have peritoneal spread.