Symposium on Hereditary Breast & Ovarian Cancers: Risk and Challenges

遗传性乳房研讨会

• 批准号: 7750173
• 负责人: FRANCO MUGGIA
• 金额: $ 1.25万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7750173
• 关键词: Accounting; Address; Breast; Cancer Etiology; Cessation of life; Characteristics; Clinical; DNA Repair; Defect; Diagnosis; Early Diagnosis; Environment; Europe; Family; Genetic; Hand; Heel; Hereditary Breast and Ovarian Cancer Syndrome; Hereditary Malignant Neoplasm; Hormonal; Individual; Inherited; International; Knowledge; Lead; Learning; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of ovary; Measures; Minority; Molecular Abnormality; Ovary; Predisposition; Prevention; Preventive; Risk; Structure; Tumor Biology; United States; Woman; cancer risk; cancer therapy; disorder risk; interest; malignant breast neoplasm; meetings; public health relevance; symposium

DESCRIPTION (provided by applicant): This international meeting on hereditary breast and ovarian cancer follows on the heels of prior individual symposia previously organized separately in Europe and in United States. The meeting structure consists of an introductory session on the general topic of prevention and early diagnosis of breast and ovarian cancer, five additional plenary sessions dealing with various aspects related to the biology of these tumors and to the clinical implications, and ending with a session including a round table that will deal with strategies in management of this problem. Although the focus of the five plenary sessions is on hereditary cancers (making up the minority of women afflicted with these cancers), it has become increasingly obvious that the lessons learned from their occurrence within families are also applicable to a variable extent to those that occur 'sporadically' -that is, without prior knowledge of a hereditary condition. In fact, the progress in prevention, diagnosis and treatment of these cancers has gone hand in hand with what is being learned in hereditary cancer: predisposition to cancer in relation to the host's hormonal environment, magnetic resonance imaging in early detection, implications of DNA- repair defects resulting from specific genetic abnormalities in causing cancer. We anticipate that this meeting, bringing together experts from two continents, and attended by interest young workers in the field will lead to discussion on a number of issues relating to disease-risks, and the challenges on how to address these risks at earlier (and more favorable) circumstances. Public Health Relevance: Cancers of the breast and ovary account for approximately 60,000 deaths annually in the United States. Hereditary cancers, although only accounting for 10% of these occurrences, lead the way in the determination of relevant genetic characteristics and in the implementation of preventive and surveillance measures. Thus this meeting will be of interest to workers dealing with all aspects of breast and ovarian cancers.

描述（由申请人提供）：本次关于遗传性乳腺癌和卵巢癌的国际会议是继之前在欧洲和美国分别组织的个人研讨会之后召开的。会议结构包括关于乳腺癌和卵巢癌的预防和早期诊断一般主题的介绍性会议，另外五场全体会议，讨论与这些肿瘤的生物学和临床意义相关的各个方面，最后的会议包括讨论该问题管理策略的圆桌会议。虽然五次全体会议的重点是遗传性癌症（在患有这些癌症的女性中占少数），但越来越明显的是，从家庭中发生的癌症中吸取的教训也可以在不同程度上适用于那些“偶发”发生的癌症，即事先不了解遗传性疾病的癌症。事实上，这些癌症的预防、诊断和治疗方面的进展与遗传性癌症的研究进展齐头并进：与宿主荷尔蒙环境相关的癌症易感性、早期检测中的磁共振成像、特定基因异常导致的DNA修复缺陷对癌症的影响。我们预计，这次会议汇集了来自两大洲的专家，并由该领域感兴趣的年轻工作者参加，将就与疾病风险有关的许多问题以及如何在更早（和更有利）的情况下应对这些风险的挑战进行讨论。 公共卫生相关性：在美国，每年约有 60,000 人死于乳腺癌和卵巢癌。遗传性癌症虽然只占这些癌症的 10%，但在确定相关遗传特征以及实施预防和监测措施方面处于领先地位。因此，处理乳腺癌和卵巢癌各个方面的工作者都会对这次会议感兴趣。