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NEURAL SUBSTRATES OF COGNITION IN AGING AND ALZHEIMER'S DISEASE

NEURAL SUBSTRATES OF COGNITION IN AGING AND ALZHEIMER'S DISEASE
衰老和阿尔茨海默病中认知的神经基础
批准号：
6305677
负责人：
SUZANNE H CORKIN
金额：
$4.04万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2001-11-30
来源：
https://reporter.nih.gov/project-details/6305677
关键词：
Alzheimer's disease aging biomarker clinical research cognition functional magnetic resonance imaging human old age (65+) human subject long term memory longitudinal human study neurophysiology psychomotor function visual perception young adult human (21-34)

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中文摘要
翻译
使用新的高速功能磁共振方法来(A)获得关于衰老和AD中特定认知变化的神经基础的线索，(B)记录这些变化中的个体差异，以及(C)识别可能预示非常早期的AD的神经生理标记物。为了实现这些目标，我们将在5年内每年对AD患者、老年对照患者和年轻对照受试者进行60项功能磁共振研究。我们将在三个易受衰老和AD影响的认知领域检验MRI信号与行为的相关性：长期外显记忆、视觉感知和运动控制。
英文摘要
To use novel high-speed fMRI methods to (a) obtain clues about the neural substrates of specific cognitive changes in aging and AD, (b) document individual differences in those changes, and (c) identify neurophysiological markers that may signal very early AD. In order to achieve these goals, we shall perform 60 fMRI studies per year over a 5-year period in subjects with AD, older control subjects, and young control subjects. We shall examine correlations between MRI signal and behavior in three cognitive domains that are vulnerable to the effects of aging and AD: long-term explicit memory, visual perception, and motor control.
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