SALINE ENHANCED RADIOFREQUENCY ABLATION FOR LIVE TUMORS

描述(改编自申请者摘要)：肝癌，尤其是 结直肠癌，是一个重大的健康问题。在美国，一半的人 在157,000例新的结直肠癌病例中， 肝脏，这将导致超过17,000人死亡。虽然不是很重要，但 健康风险随着结直肠转移，肝细胞癌正在 确诊的频率越来越高。现行的业务标准是 肝癌的治疗是手术切除，但只有10%的患者是这样做的 有资格接受这一程序。使用射频的热消融是一种 前景看好的替代疗法，但它只能治疗小肿瘤。这个 申请者建议继续开发生理盐水增强射频 治疗大肝肿瘤的消融系统。该系统使用射频 能量来加热组织，但这将与同步 通过电极向组织内注射温生理盐水 盐分流过细胞外空间，并将热能对流 深入组织。因此，有可能显著地治疗 比以前可能的更大的肿瘤体积。据报道，这项技术 创建的热损伤的体积是所创建的体积的90倍 使用传统的射频电极。因此，该方法将使 经皮热消融疗法将用于较大的肿瘤，大大 增加有资格接受治疗的患者数量。 建议的商业应用：不可用

DESCRIPTION (Adapted from Applicant's Abstract): Liver cancer, especially colorectal cancer, is a significant health concern. In the United States, half of the 157,000 new cases of colorectal cancer will lead to metastases in the liver, which will lead to over 17,000 deaths. And while not as significant a health risk as colorectal metastasis, hepatocellular carcinoma is being diagnosed with increasing frequency. The current standard of practice for treating liver cancer is surgical resection, but only 10% of patients are eligible for this procedure. Thermal ablation using radiofrequency is a promising alternative therapy, but it can only treat small tumors. The applicants propose to continue development of a saline-enhanced radiofrequency ablation system for treating large liver tumors. The system uses radiofrequency energy to heat tissue, but this would be complimented with simultaneous injection of warm saline through the electrode and into the tissue The injected saline flows through the extracellular space and convects the thermal energy deep into the tissue. Consequently, it would be possible to treat significantly larger tumor volumes than previously possible. The technique has been reported to created thermal lesions whose volumes are 90 times as large as those created with conventional radiofrequency electrodes. The method would therefor enable percutaneous thermal ablation therapy to be used on larger tumors, greatly increasing the number of patients eligible for therapy. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE