MULTIDISCIPLINARY TRAINING IN EXPERIMENTAL HEMATOLOGY

本申请请求支持建立一个新的多学科血液病研究培训计划。血液病仍然是美国境内发病率和死亡率的主要来源。梅奥诊所培训学术血液学家的传统由来已久。最近的分析表明，梅奥诊所血液学/肿瘤学临床奖学金计划的应届毕业生中，约有一半在获得奖学金后承担了实验室研究任务。为了更好地装备这些学术内科医生以及对血液病感兴趣的合适的博士科学家，以便随后进行假设驱动的实验室研究，我们设计了血液学研究培训计划。培训人员由32名外部资助的研究人员组成，他们的实验室研究项目包括1)髓系和淋巴系统恶性肿瘤，2)细胞因子，3)凝血和微循环，4)分子治疗学，5)实验免疫学，6)临床和遗传流行病学。每个受训人员将被期望在这些培训教师之一的实验室完成至少两年的假设驱动的研究。这种实践研究经验将通过参加生物化学和分子生物学研讨会、血液学核心教学讲座分部和GCRC关于“研究的实践方面”的课程来补充。此外，还将鼓励学员根据需要选修生物化学、免疫学、分子生物学、生理学、分子药理学或肿瘤生物学课程，以扩大他们在与其研究项目相关的领域的知识基础。我们最初建议每年招聘1-2名实习生，稳定状态计划为3名实习生。血液学研究培训计划将由斯科特·考夫曼医学博士和罗伯特·A·凯尔医学博士共同指导，他们两人都是由外部资助的研究人员，项目重点是血液疾病。该项目将由一个包括考夫曼博士和凯尔博士在内的四人委员会管理。我们将寻找具有医学博士、博士或医学博士/博士背景的合格候选人。建立了积极招聘合格的少数群体和妇女候选人的机制。这一计划是现有血液学培训机会的自然产物，但将为血液学疾病的实验室研究提供更好的准备。(摘要结束)

DESCRIPTION (Applicant's Abstract) This application requests support to establish a new multidisciplinary research training program in hematological diseases. Hematological diseases remain a major source of morbidity and mortality within the United States. The Mayo Clinic has a long tradition of training academic hematologists. Recent analysis indicates that approximately half of the recent graduates of the Mayo Clinic hematology/oncology clinical fellowship program have laboratory research commitments following fellowship. To better equip these academic physicians, as well as suitable Ph.D. scientists interested in hematological diseases, for subsequent pursuit of hypothesis-driven laboratory investigation, we have designed a Hematology Research Training Program. The training faculty consist of 32 extramurally funded investigators with laboratory research programs in 1) myeloid and lymphoid malignancies, 2) cytokines, 3) coagulation and microcirculation, 4) molecular therapeutics, 5) experimental immunology, and 6) clinical and genetic epidemiology. Each trainee will be expected to complete at least two years of hypothesis-driven research in the laboratory of one of these training faculty. This hands-on research experience will be supplemented by required attendance at Biochemistry & Molecular Biology seminars, Division of Hematology Core didactic lectures, and a GCRC course on "Practical Aspects of Research." In addition, trainees will be encouraged to take additional biochemistry, immunology, molecular biology, physiology molecular pharmacology or tumor biology courses as needed to extend their knowledge bases in areas related to their research projects. We initially propose to recruit 1-2 trainees per year, with a steady state program of three trainees. This Hematology Research Training Program will be co-Directed by Scott Kaufmann, M.D., Ph.D., and Robert A. Kyle, M.D., both of whom are extramurally funded investigators with programs focused on hematological diseases. The program will be administered by a four member committee that includes Drs. Kaufmann and Kyle. We will seek qualified candidates with M.D., Ph.D., or M.D./Ph.D. backgrounds. Mechanisms are in place for aggressive recruitment of qualified minority and women candidates. This program is a natural outgrowth of existing training opportunities in hematology, but will provide better preparation for laboratory research in hematological diseases. (End of Abstract)