MOLECULAR MECHANISMS OF LUNG INFLAMMATION

(根据申请者的摘要改编)本计划的目的是培训 年轻的博士后研究人员(2名博士和2名医学博士)发展技能，使之 将使他们能够在分子生物学和 人类肺部疾病的病理生理学。这种培训的必要性 该计划最近在9月9日的一次Spark会议上概述。1998年，在 贝塞斯达，医学博士，NHLBI。特别是新的多学科方法 需要对年轻的调查人员进行培训，使他们熟悉 分子生物学和免疫学与心、肺、血 病理生理学“在这个节目中将特别强调 培训调查人员在攻击中使用多学科方法 关于认识起源和发现新事物的基本问题 治疗肺病的药物。培训人员是被有目的地挑选出来的 提供跨越此范围的广泛培训环境，包括 专业知识包括分子遗传学、免疫细胞功能、功能 基因组学，肺上皮细胞功能，细胞信号，自由基生物学， 线粒体生物学和肺血管病理生理学。目标1)至 提供足够的讲授、互动和分子技术背景 生物学、免疫学、细胞信号、自由基生物学和功能 基因组学使学员能够轻松地在这些学科之间移动 目标2)制定一项创新计划，确保受训人员 迅速转化为直接的动手实验室体验，很可能是 成功。目标3)使受训者沉浸在创造性的环境中 以及一种积极的研究氛围，确保最大可能 他们的成功和他们在科学研究人员和 老师们。此外，还将提供道德和道德方面的具体培训。 一种研究哲学，目的是培养出将 在最高水平的智力诚信下运作。目标4) 制定长期方案，鼓励妇女和少数群体追求 在肺部科学和研究方面的职业，更重要的是建立 培训计划中有足够的基础设施和支持系统，以 确保积极进取的实习生取得成功。

(Adapted from applicant's abstract) The purpose of this program is to train young postdoctoral investigators (2 Ph.D. and 2 M.D.) To develop skills that will allow them to bridge the interface between molecular biology and the pathophysiology of human pulmonary disease. The need for this training program was recently outlined at a SPARK Conference, Sept. 1998, held in Bethesda, M.D. b the NHLBI. "In particular, new multidisciplinary approaches are needed to train young investigators conversant with the common language of molecular biology and with immunology and heart, lung and blood pathophysiology." Particular emphasis will be placed in this program upon training investigators to use multidisciplinary approaches in attacking fundamental problems related to understanding the origins and finding new cures for lung disease. The training faculty were purposefully selected to provide a wide range of training environments that cross this spectrum, with expertise including molecular genetics, immune cell function, functional genomics, lung epithelial cell function, cell signaling, free radical biology, mitochondrial biology and lung and vascular pathophysiology. Objectives 1) To provide sufficient didactic, interactive and technical background in molecular biology, immunology, cell signaling, free radical biology and functional genomics to allow trainees to be able to move easily between these disciplines Objective 2) To develop an innovative program which ensures that trainees move rapidly into direct hands-on laboratory experiences that are likely to be successful. Objective 3) To immerse the trainees in a creative environment and a positive research atmosphere which ensures the greatest possibility for their success and their retention in the ranks of scientific investigators and teachers. In addition, specific training will be provided in the ethics and philosophy of research with the intent of producing scientists who will operate at the highest levels of intellectual integrity. Objective 4) To develop long range programs which encourage women and minorities to pursue careers in pulmonary science and research and more importantly to build sufficient infrastructure and support systems within the training program to ensure the success of the motivated trainee.