SOUTHERN CALIFORNIA AIDS MALIGNANCY NETWORK

描述：（申请人的描述） 艾滋病基金会成立于1994年，自1995年以来， 由五个地点组成：加州大学旧金山分校，加州大学洛杉矶分校，乔治华盛顿大学， 纽约州立大学布鲁克林分校和俄亥俄州州立大学。 AMB是国家资源 这反映了样本中艾滋病的恶性肿瘤的历史。 因为AMB的科学家们自己也积极参与了 在艾滋病相关恶性肿瘤的发生过程中，AMB对 艾滋病毒疾病的治疗和科学进展。 目前，AMB 包含43个不同类别的12，688个个体标本。 这些 液体、细胞和组织标本，沿着相关临床 信息，提供给世界各地合格的研究人员。 迄今为止， 不同的研究人员收到了900多个标本， 由独立研究机构对其意向书（LOI）进行评估， 评价决定小组（REDP）的专家在该领域。 目前的重新竞争建议结合了所有AMB的信息 成员网站，以及报告成就，未来计划，目标和 各站点的预算预测。 AMB的主要目标是：1） 建立一个运营中心，负责维护国家数据库， 协调AMB站点的活动，并与外部资源进行接口 艾滋病相关的艾滋病联盟和妇女组织等标本的 机构间艾滋病毒研究和科学界; 2）扩大AMB， 作为大型肿瘤临床的标本库， 流行病学财团，最终导致采购他们的 标本; 3）增加知名度和扩大使用AMB的， 研究者;以及4）进一步开发个体成员研究中心计划 以增加样本采集。 UCLA AMB是最初的资助银行之一。 迄今为止， 超过三分之一的案件在AMB（579 1503例）和第三 最高的样本总数。 该银行发行了最大的 向18名获批研究者中的5名提供标本采集。 加州大学洛杉矶分校 AMB一直积极参与AMB指导委员会的工作，并领导努力， 来自其他群体的样本，如艾滋病相关恶性肿瘤财团 到AMB。 加州大学洛杉矶分校的AMB正在重新配置，以扩大其范围， 标本，增加其获得神经和多部位尸检组织的机会， 并在主站点对其他储存的标本进行编目。 在这 更新后，加州大学洛杉矶分校将从目前的三家医院扩大到10多家医院。 这些医院为90%以上艾滋病毒感染者提供治疗， 洛杉矶县。 我们还将增加一个国际公认的艾滋病毒 神经病理学家 随着这些变化，我们预计将增加1000多个 新增病例和5,000多个新样本 UCLA AMB还预计， 通过其领导层将AMC的16，000多个标本带入AMB AMC临床试验002、007和009。 在接下来的五年里，UCLA AMB打算扩大其在AMB中的领导地位。

DESCRIPTION: (Applicant's Description) The AIDS Malignancy Bank was established in 1994, and since 1995 has been composed of five sites: UCSF, UCLA, George Washington University, SUNY-Brooklyn, and Ohio State University. The AMB is a national resource that reflects the history of the malignancies of HIV disease in specimens. Because scientists in the AMB are themselves actively involved in studies of the p a t hogenesis of AIDS-related malignancies, the AMB is responsive to therapeutic and scientific advances in HIV disease. Currently, the AMB contains 12,688 individual specimens in 43 different categories. These fluid, cell, and tissue specimens, along with associated clinical information, are available to qualified researchers worldwide. To date, 18 different investigators have received over 900 specimens after critical evaluation of their Letters of Intent (LOIs) by an independent Research and Evaluation Decision Panel (REDP) of experts in the field. This current re-competition proposal combines information from all AMB member sites, as well as reporting accomplishments, future plans, goals and budget projections from individual sites. The key AMB goals are: 1) to establish an Operations Center that will maintain the national database, coordinate activities of the AMB sites, and interface with external sources of specimens such as the AIDS-related Malignancy consortium and the Women's Interagency HIV Study, and the scientific community; 2) to expand the AMB to serve as the specimen repository for large oncological clinical and epidemiological consortia, ultimately leading to procurement of their specimens; 3) to increase visibility and broaden the use to the AMB by investigators; and 4) to f u rther develop individual member site programs to increase specimen acquisition. The UCLA AMB was one of the original funded banks. To date, it has accrued over one third of all cases in the AMB (579 of 1503 cases) and the third highest total of specimens overall. The bank has distributed the largest collection of specimens to five of the 18 approved investigators. The UCLA AMB has been active in the AMB steering committee and led efforts to bring samples from other groups such as the AIDS associated malignancy consortium to the AMB. The UCLA AMB is being reconfigured to expand its reach for specimens, increase its access to neurologic and multi-site autopsy tissues, and catalogue additional stored specimens at the main site. In this renewal, UCLA will expand from its current three hospitals to over 10 hospital that provide care to over 90% of all patients with HIV infection in LA County. We will also add an internationally recognized HIV neuropathologist. With these changes, we anticipate accruing over 1,000 additional cases and over 5,000 new specimens. The UCLA AMB also expects to bring over 16,000 specimens from the AMC into the AMB through its leadership of AMC clinical trials 002, 007 and 009. Over the next five years, the UCLA AMB intends to expand its leadership position within the AMB.