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EMF AND BREAST CANCER ON LONG ISLAND

EMF AND BREAST CANCER ON LONG ISLAND
长岛的电磁场与乳腺癌
批准号:
6334151
负责人:
MCRISTINA LESKE
金额:
$16.54万
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-09-30 至 2001-02-28

项目摘要

项目成果

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中文摘要
翻译
长岛的乳腺癌发病率在2000年以来一直在上升。 过去几年拿骚和萨福克县都是最高的, 纽约州的发病率高于美国全国 长岛乳腺癌研究,一项大型病例对照研究, 在20世纪80年代中期进行的一项研究发现,标准的风险因素只能解释 一小部分的额外发病率。 因此,我们建议 一项研究,研究了几个环境因素, 据推测与乳腺癌有关。 最近对实验室动物的研究表明, 大约60赫兹的电磁辐射(EMF)可能与乳腺癌有关, 抑制松果体分泌褪黑激素。通过减少 褪黑激素分泌,它可以增加雌激素的产生,以及 乳腺癌的危险因素。此外,最近几次 小规模的研究发现, 乳腺癌患者乳腺脂肪组织中有机氯化合物的研究 比对照组。最近的这些报道引起了龙的极大关注 岛上的妇女,由于电磁辐射的高使用率和 在长岛,有机氯农药的使用量很高。 因此,我们建议进行一项病例对照研究, 控制女性的癌症病例。这项研究将仅限于那些 在同一所房子里住了至少15年。EMF测量 将在这些住宅内外制造, 将对这些妇女的血清进行分析。家居尘埃样本 将对随机抽取的女性样本进行分析。水平 血清和粉尘中有机氯农药残留量比较 样品 此外,还将发放一份详细的问卷, 每个参与者为了获得有关环境的信息, 暴露和标准乳腺癌风险因素。希望这一 研究将有助于阐明乳腺癌高发的原因 在长岛发生的事件
英文摘要
The incidence of breast cancer on Long Island has been increasing over the past few years. Both Nassau and Suffolk Counties rank among the highest in New York State, which itself has a higher incidence than the U.S. national average.The Long Island Breast Cancer Study, a large case-control study conducted in the mid 1980's found that standard risk factors explain only a fraction of the excess incidence. Therefore, we are proposing this study to examine several environmental factors which have been hypothesized to be associated with breast cancer. Recent work with laboratory animals has suggested that electromagnetic radiation (EMF) of about 60 hz might be associated with breast cancer by inhibiting secretion of melatonin by the pineal gland. By reducing melatonin secretion, it could be increasing estrogen production, a well established risk factor for breast cancer. In addition, several recent small-scale studies found higher levels of environmentally widespread organochlorine compounds in breast adipose tissue of breast cancer cases than controls. These recent reports have created much concern among Long Island women, given the high usage of electromagnetic radiation and the previously high usage of organochlorine pesticides on Long Island. We are therefore proposing to do a case-control study comparing breast cancer cases to control women. The study will be limited to those women residing in the same house for at least fifteen years. EMF measurements will be made both inside and outside these residences, and chemical analyses will be done on serum from these women. Household dust samples will be collected and analyzed on a random sample of women. Levels of organochlorine pesticide residues will be compared between serum and dust samples. In addition, a detailed questionnaire will be administered to each participant in order to gain information regarding environmental exposures and standard breast cancer risk factors. It is hoped that this study will help to clarify the reasons for the high breast cancer incidence on Long Island.
期刊论文(6)
专著(0)
科研奖励(0)
会议论文
Wire coding in the EMF and Breast Cancer on Long Island Study: relationship to magnetic fields.
长岛电磁场和乳腺癌研究中的电线编码:与磁场的关系。
DOI: 10.1038/sj.jea.7500280
发表时间: 2003
期刊: Journal of exposure analysis and environmental epidemiology.
影响因子: --
作者: [O'Leary,ErinS, Schoenfeld,ElinorRandi, Henderson,Kevin, Grimson,Roger, Kabat,GeoffreyC, Kaune,WillamT, Gammon,MarilieD, Leske,MCristina, EBCLISGroup]
通讯作者: EBCLISGroup
Breast cancer and electromagnetic fields--a review.
乳腺癌和电磁场——综述。
DOI: 10.1016/s1047-2797(99)00043-5
发表时间: 2000
期刊: Annals of epidemiology
影响因子: 5.6
作者: [Caplan,LS, Schoenfeld,ER, O'Leary,ES, Leske,MC]
通讯作者: Leske,MC
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