PREVENTIVE ONCOLOGY ACADEMIC AWARD

描述：(申请人的描述)提议的计划将为我提供 为长期从事癌症流行病学工作奠定了基础 预防。通向这一目标的途径是熟练掌握 分子流行病学，它有望促进我们对这两种疾病的了解 癌症病因学和癌症预防，增加了我既定的技能 在流行病学方法中。双管齐下的教育和研究 是提议的。 这项教育计划的目的是：1)扩大我的分子知识 2)提高我的教学和沟通能力。这个 前一个目标将通过以讨论为导向的课程作业来实现 论坛，并得到研究计划的加强。朝着后一个目标前进， 我将参加有关流行病学方法和癌症的教学课程 流行病学。我还将在社区环境中工作，以提高 与决策者沟通。 该研究计划包括三项研究，重点是结肠癌。 第一阶段是一项吸烟与以下因素相关的前瞻性队列研究 患结肠癌的风险。阶段2为嵌套式病例对照研究 评估吸烟、饮食和基因多态之间的关系 与结肠相关的编码致癌物代谢酶的基因 癌症风险。第三阶段是一项横断面研究，研究对象为 生活方式实践和癌症预防行为将导致 制定癌症控制计划。这个研究项目的结果是， 在增进我们对结肠癌病因的认识的同时， 可能最多的人群中适用的易感人群亚群 风险。 通过加强我在分子流行病学方面的背景，该提案计划 将建立在癌症流行病学和预防方面的先前经验 将使我能够从事广泛的研究，旨在 预防癌症。

DESCRIPTION: (Applicant's Description) The proposed plan will provide me with a foundation for a long-term career in cancer epidemiology and prevention. The pathway outlined toward this goal is to gain proficiency in molecular epidemiology, which holds promise to advance our knowledge of both cancer etiology as well as cancer prevention, adding to my established skill in epidemiologic methods. A two-pronged approach of education and research is proposed. The educational plan is designed to: 1) expand my knowledge of molecular epidemiology and 2) enhance my teaching and communication skills. The former goal will be addressed through course work, discussion-oriented forums, and be reinforced by the research program. Toward the latter goal, I will participate in teaching classes on epidemiologic methods and cancer epidemiology. I will also work in community setting to enhance skills in communicating with decision-makers. The research plan consists of three studies with a focus on colon cancer. Phase 1 is a prospective cohort study of cigarette smoking in relation to the risk of colon cancer. Phase 2 is a nested case control study to evaluate the relationships of cigarette smoking, diet, and polymorphisms in genes that encode carcinogen metabolizing enzymes in relation to colon cancer risk. Phase 3 is a cross-sectional study of the prevalence of lifestyle practices and cancer prevention behaviors that will lead to the development of a cancer control plan. The results of this research program, while contributing to our knowledge of the etiology of colon cancer, will be applicable susceptible subgroups of the population who may be at greatest risk. By strengthening my background in molecular epidemiology, the proposal plan will build upon previous experience in cancer epidemiology and prevention and will enable me to engage in a broad range of research geared toward the prevention of cancer.