MUTAGENICITY TESTING IN SALMONELLA

这份合同的目标是测试大约25个 使用体外沙门氏菌检测每年化学品的致突变性 致突变性试验。沙门氏菌检测已被广泛接受为 一种化学物质在高等生物体中潜在诱变性的指示物， 并具有致癌性。接受测试的化学物质将从 在被提议具有致突变性、致癌性或 生殖毒性测试，或对 国家毒物学计划或国家毒理学研究所的其他计划 环境健康科学。 从这份合同中获得的结果将用于帮助 确定短期和长期动物试验的优先事项，并将 提供有关行动机制的信息以支持 对长期动物毒性结果的解释。完成 这些研究还将为进一步发展基因 毒性数据库，将用于确定协议的级别 体内和体外遗传毒性试验及其预测性的比较 关于啮齿动物致癌的体外结果。

The objective of this contract is to test approximately twenty-five chemicals per year for mutagenicity using the in vitro Salmonella mutagenicity test. The Salmonella test has become widely accepted as an indicator of a chemical's potential mutagenicity in higher organisms, and of carcinogenicity. The chemicals tested will be selected from among those that are proposed for mutagenicity, carcinogenicity, or reproductive toxicity testing, or are of special interest to the National Toxicology Program or others in the National Institute of Environmental Health Sciences. The results obtained from this contract will be used to assist in setting priorities for short- and long-term animal testing, and will provide information on mechanisms of action to support the interpretations of long-term animal toxicity results. Completion of these studies will also allow for the further development of the genetic toxicity database which will be used to determine the level of agreement between in vivo and in vitro genetic toxicity tests and the predictivity of in vitro results for rodent carcinogenesis.